Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 200, Issue -, Pages 1-11Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.12.133
Keywords
Electrostatic self-assembly; Biocompatible; Antibacterial; Bioadhesion; Sodium alginate/epsilon-polylysine fiber
Funding
- National Key Research and Development Program of China [2017YFD0400803]
- National Natural Science Fund of China [NSFC 32072310]
- National Food Science and Engineering first-class discipline construction project [JUFSTR20180204]
Ask authors/readers for more resources
A novel filamentous sodium alginate (SA) / epsilon-polylysine (PL) fiber with excellent properties and controllable sizes is prepared in an environmentally friendly manner. The SA/PL fiber exhibits antibacterial activity, low cytotoxicity, anti-hemolysis, bioadhesion, and environmental friendliness. In vivo experiments have shown that the SA/PL fiber promotes wound healing by resisting pathogen infection, reducing inflammation, and preventing allergies.
In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA. The SA/PL fiber exhibits good antibacterial activity, low cytotoxicity, anti-hemolysis, bioadhesion, and environmental friendliness due to its natural raw materials and green preparation process. In vivo experiments have shown that the SA/PL fiber can promote the healing and repair of skin wounds on the backs of mice via resistance to pathogen infection, reduction of inflammation, and anti-allogeneic allergy of the wound. In summary, these results demonstrate that the SA/PL fiber is a green and biosafe multifunctional natural polymer material, with potential applications in suturing wound.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available