4.7 Review

Recent progress of collagen, chitosan, alginate and other hydrogels in skin repair and wound dressing applications

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 208, Issue -, Pages 400-408

Publisher

ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.03.002

Keywords

Wound dressings; Collagen; Chitosan

Funding

  1. National Natural Science Foundation of China [31971251]
  2. National Key Research and Development Program of China [2018YFC1106800, 2019YFA0110600]
  3. 135 project for disciplines of excellence, West China Hospital Sichuan University [ZYGD21001, ZYJC21026, ZYJC21077]
  4. Project of Chengdu Science and Technology Bureau [2021-YF05-01619-SN]
  5. Sichuan University Panzhihua science and technology cooperation project [2021CDPZH-4]
  6. Science and Technology Project of Tibet Autonomous Region [XZ201901-GB-08]

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This review summarizes the recent progress in skin repair and wound dressing regeneration biomaterials research, including clinical research, classification, composition, performance, and biological function characteristics of different biomaterials. The future development direction is also discussed.
Human understanding of skin is constantly ongoing. Great progress has been made in skin repair, wound dressing regeneration biomaterials research in recent years. This review introduced the clinical research and guiding principles of skin repair, wound dressing biomaterials at home and abroad, introduced the classification of various skin repair and wound dressing, listed the composition and performance of different dressing biomaterials, including traditional, natural, synthetic, tissue-engineered dressing materials were extensively reviewed. The biological molecular structures and biological function characteristics of different dressing biomaterials are comprehensively reviewed. Collagen, chitosan, alginate hydrogels et al. as the most popular biological macromolecules in skin repair and wound dressing applications were reviewed. The future development direction is also prospected. This paper reviews the research progress of advanced functional skin repair and wound dressing, which provides a reference for the modifications and applications of wound dressings.

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