Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 107, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2022.108637
Keywords
mtDNA; Mitochondria; Inflammation; Kidney diseases
Categories
Funding
- National Natural Science Foundation of China [81730018]
- National Key R&D Program of China [2018YFC1314002]
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This article discusses the role of mitochondrial DNA in kidney diseases, with a focus on its leakage into the cytoplasm and inflammatory activation pathways. By elucidating the importance of mtDNA in kidney diseases, it provides a direction for future research.
Mitochondrial dysfunction and nonbacterial inflammation are common pathogenesis of acute kidney injury (AKI) and chronic kidney disease (CKD). However, the pathophysiology of kidney disease has not been completely elucidated. Mitochondria have their own DNA, namely mitochondria DNA (mtDNA), which encodes key proteins in the mitochondrial respiratory complex. Leakage of mtDNA into the cytoplasm can lead to inflammation and this process has been reported to be involved in the development of a variety of diseases. Here we discuss the structure and function of mtDNA, more specifically, to emphasize it leaks into the cytoplasm and inflammatory activation pathways. Finally, the role of mtDNA in kidney diseases is also summarized and provides a direction for future research.
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