Evaluation of antioxidant, cytotoxicity, and anti-ovarian cancer properties of the Fe3O4@CS-Starch/Cu bio-nanocomposite

In the recent days, conjugated bio-nanomaterials involving magnetic core are interested as promising platform in new generation biological composites. In this regard, we report herein a novel Cu NPs supported chitosan-starch composite functionalized Fe3O4, a dual core-shell type nanoparticle (Fe3O4@CS-Starch/Cu). The post synthetically modified biogenic material was analyzed in details over a number of physicochemical methods like, Transmission Electron Microscope (TEM), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray Diffraction (XRD), energy-dispersive X-ray analysis (EDX), vibrating sample magnetometer (VSM) and inductively coupled plasma (ICP) techniques. In the medicinal part, the anticancer properties of Fe3O4@CS-Starch/Cu against ovarian cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC(50 )were 198 and 155 mu g/ml against Fe3O4@CS-Starch/Cu bionanocomposite and BHT. The IC50 of the Fe3O4@CS-Starch/Cu bio-nanocomposite were 248, 189, and 281 mu g/mL against ovarian cancer (PA-1, SW-626, and SK-OV-3) cell lines. In addition, the current study offer that Fe3O4@CS-Starch/Cu bio-nanocomposite could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells.

Automated summary

Conjugated bio-nanomaterials with magnetic core have attracted attention as a promising platform for new generation biological composites. In this study, a novel Cu NPs supported chitosan-starch composite functionalized Fe3O4, a dual core-shell type nanoparticle (Fe3O4@CS-Starch/Cu), was reported. The post synthetically modified biogenic material was comprehensively analyzed using various physicochemical methods. The anticancer properties of Fe3O4@CS-Starch/Cu against ovarian cancer cell lines were evaluated, and the results indicated its potential as an adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells.