4.5 Article

Natural History of New-onset Inflammatory Bowel Disease Among Patients With Multiple Sclerosis

Journal

INFLAMMATORY BOWEL DISEASES
Volume 28, Issue 10, Pages 1614-1617

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izac053

Keywords

Autoimmune disease; Demyelination; Anti-TNF therapy

Funding

  1. NIH/NIDDK [K23DK117058, R03DK129631]
  2. AbbVie
  3. Takeda

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Patients with both MS and IBD had similar rates of stricturing, fistulizing, and extensive IBD compared to IBD controls. Although MS-IBD patients were less likely to start anti-TNF therapy, their risk of surgery did not worsen during follow-up.
Lay Summary Patients with MS and IBD were as likely to have stricturing, fistulizing, and extensive IBD as IBD controls. Although MS-IBD patients were less likely to initiate anti-TNF therapy, they did not have worsened risk of progression to surgery on follow-up.

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