Journal
INFECTION GENETICS AND EVOLUTION
Volume 102, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2022.105302
Keywords
Pseudomonas aeruginosa; ST277; KPC; SPM
Categories
Funding
- Fundacao Carlos Chagas Filho de Amparoa Pesquisa do Estado do Rio de Janeiro -FAPERJ [E-26/202.554.2019]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico -CNPq [402524/2018-7]
- Projeto Redes FAPERJ [E-26/211554/2019]
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The high rates of carbapenem resistance among Brazilian Pseudomonas aeruginosa isolates are mainly associated with the clone ST277 producing the carbapenemase SPM-1. The complete genetic composition of a IncP plasmid harboring blaKPC-2 in isolates of this endemic clone carrying chromosomal blaSPM-1 was described using whole genome sequencing. These results confirm the association of these two carbapenemases in ST277 and also describe the genetic composition of a novel blaKPC-2-plasmid. Considering the fact that this association occurs in a high-risk clone, monitoring the dissemination of this plasmid should be a public health concern.
The high rates of carbapenem resistance among Brazilian Pseudomonas aeruginosa isolates are mainly associated with the clone ST277 producing the carbapenemase SPM-1. Here, the complete genetic composition of a IncP plasmid harboring blaKPC-2 in isolates of this endemic clone carrying chromosomal blaSPM-1 was described using whole genome sequencing. These results confirm the association of these two carbapenemases in ST277 and also describe the genetic composition of a novel blaKPC-2-plasmid. Considering the fact that this association occurs in a high-risk clone, monitoring the dissemination of this plasmid should be a public health concern.
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