Fe3O4@MoS2/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

ABSTRACT: Cancer treatment by chemotherapy exploits one or more anticancer drugs to kill cancer cells. Because of the various side effects of chemotherapy drugs, sensitive determination of these drugs is one of the greatest challenges of adjuvant therapy. This study introduced the preparation of a selective and sensitive electrochemical sensor based on a carbon paste electrode (CPE) modified with Fe3O4@MoS2/reduced graphene oxide nanocomposite and ionic liquid (IL) (Fe3O4@MoS2/rGO/ILCPE) to determine dasatinib in the presence of doxorubicin. Results showed very good electrocatalytic activities of Fe3O4@MoS2/rGO/ILCPE toward the oxidation of dasatinib in phosphate buffer solution (PBS) (pH 7.0). The differential pulse voltammetry (DPV), chronoamperometry, and cyclic voltammetry (CV) were employed for studying the electrochemical behaviors of dasatinib on the modified electrode. Based on the optimal condition, we observed a linear increase of the voltammetric current by enhancing the dasatinib concentration in ranges between 0.02 mu M and 390.0 mu M. The detection limit for the dasatinib was equal to 6.0 nM, based on 3Sb/ m. Moreover, the modified CPE was used for the detection of dasatinib in the presence of doxorubicin. The corresponding electrochemical signals emerged as two well-resolved oxidation peaks with the considerable peak potential differences of 0.38 V. Finally, dasatinib and doxorubicin detection in the real samples were estimated by examining the functionality of our new sensor that showed acceptable recovery.

Automated summary

This study developed a sensitive electrochemical sensor based on a carbon paste electrode for accurate detection of the anticancer drug dasatinib. The sensor showed excellent electrocatalytic activity towards dasatinib, enabling reliable detection at low concentrations and effective detection in the presence of doxorubicin.