Journal
IMMUNITY
Volume 55, Issue 3, Pages 393-404Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2022.02.006
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Funding
- Merck KGaA, Darmstadt, Germany
- Chan Zuckerberg Initiative (CZI)
- HHMI International Scholar award
- European Research Council Consolidator Grant (ERC-COG) [724471-HemTree2.0]
- SCA award of the Wolfson Foundation
- Thompson Family Foundation
- MRA Established Investigator Award [509044]
- Israel Science Foundation [703/15]
- Ernest and Bonnie Beutler Research Program for Excellence in Genomic Medicine
- Helen and Martin Kimmel award for innovative investigation
- NeuroMac DFG/Transregional Collaborative Research Center Grant
- In-ternational Progressive MS Alliance/NMSS [PA-1604 08459]
- Adelis Foundation grant
- EMBO YIP
- Singapore Immunology Network core funding (A*STAR)
- Singapore NRF Senior Investigatorship [NRFI2017-02]
- INSERM
- Gustave Roussy
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The immune system is a complex, dynamic, and plastic ecosystem composed of multiple cell types. The advent of single-cell genomic approaches has revolutionized our knowledge of the cellular and molecular makeup of the immune system. Integration of multiomics at the single-cell level will pave the way for future advances in immunology research and clinical translation.
The immune system is a complex, dynamic, and plastic ecosystem composed of multiple cell types that constantly sense and interact with their local microenvironment to protect from infection and maintain homeostasis. For over a century, great efforts and ingenuity have been applied to the characterization of immune cells and their microenvironments, but traditional marker-based and bulk technologies left key questions unanswered. In the past decade, the advent of single-cell genomic approaches has revolutionized our knowledge of the cellular and molecular makeup of the immune system. In this perspective, we outline the past, present, and future applications of single-cell genomics in immunology and discuss how the integration of multiomics at the single-cell level will pave the way for future advances in immunology research and clinical translation.
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