Virus Detection using Second Harmonics of Magnetic Nanoparticles

Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R-24) and the ratio of the third harmonic to the fifth harmonic (R-35) shows that R-24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection. (c) 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.

Automated summary

In this letter, a virus detection method using the second harmonics is proposed to improve the signal intensity. The second harmonic signal to noise ratio is approximately three times higher than that of the third harmonic. The ratio of the second harmonic to the fourth harmonic is found to be more sensitive in identifying changes in virus concentration. The proposed method has the potential for rapid screening in virus detection.