Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 196, Issue -, Pages 32-46Publisher
ELSEVIER
DOI: 10.1016/j.jad.2016.02.013
Keywords
Affective temperament; Temperament evaluation Memphis Pisa; Paris and San Diego Auto-questionnaire 110 item version (TEMPS-A-110); TEMPS; Major depression: bipolar disorder.
Categories
Funding
- BMS
- Feinstein Institute for Medical Research
- Janssen/J J
- National Institute of Mental Health (NIMH)
- National Alliance for Research in Schizophrenia and Depression (NARSAD)
- Otsuka
- Takeda
Ask authors/readers for more resources
Background: The Temperament Evaluation Memphis, Pisa, Paris and San Diego Auto-questionnaire (TEMPS) is validated to assess temperament in clinical and non-clinical samples. Scores vary across bipolar disorder (BD), major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), borderline personality disorder (BPD) and healthy controls (HCs), but a meta-analysis is missing. Methods: Meta-analysis of studies comparing TEMPS scores in patients with mood disorders or their first-degree relatives to each other, or to a psychiatric control group or HCs. Results: Twenty-six studies were meta-analyzed with patients with BD (n= 2025), MDD (n=1283), ADHD (n=56) and BPD (n=43), relatives of BD (n=436), and HCs (n=1757). Cyclothymic (p < 0.001) and irritable TEMPS scores (p < 0.001) were higher in BD than MDD (studies =12), and in MDD vs HCs (studies = 8). Cyclothymic (p < 0.001), irritable (p < 0.001) and anxious (p =0.03) scores were higher in BD than their relatives, who, had higher scores than HCs. No significant differences emerged between ADHD and BD (studies = 3); Conclusion: Affective temperaments are on a continuum, with increasing scores ranging from HCs through MDD to BD regarding cyclothymic and irritable temperament, from MDD through BD to HC regarding hyperthymic temperament, and from HC through BD relatives to BD regarding cyclothymic, irritable and anxious temperament. Depressive and anxious temperaments did not differ between BD and MDD, being nonetheless the lowest in HCs. BD did not differ from ADHD in any investigated TEMPS domain. Limitations: Different TEMPS versions, few studies comparing BD with ADHD or BPD, no correlation with other questionnaires. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available