Journal
IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING
Volume 16, Issue 2, Pages 164-174Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTSP.2021.3134073
Keywords
Proteins; Coronaviruses; COVID-19; Immune system; Amino acids; RNA; Nose; COVID-19; light intensity; nucleocapsid protein; optical detection; SARS-CoV-2
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Funding
- Zayed Center for Health Sciences (ZCHS), UAE University [31R129]
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This work presents an opto-electrical method to differentiate between SARS-CoV-2 negative and positive nasal swab samples by measuring the interactions between the viral nucleocapsid protein and anti-N antibody. The study found that if the extracted feature value is greater than 1, SARS-CoV-2 can be detected in patient nasal swab samples within two minutes; otherwise, the sample is considered negative.
This work presents an opto-electrical method that measures the viral nucleocapsid protein and anti-N antibody interactions to differentiate between SARS-CoV-2 negative and positive nasal swab samples. Upon light exposure of the patient nasal swab sample mixed with the anti-N antibody, charge transfer (CT) transitions within the altered protein folds are initiated between the charged amino acids side chain moieties and the peptide backbone that play the role of donor and acceptor groups. A Figure of Merit (FOM) was introduced to correlate the relative variations of the samples with and without antibody at two different voltages. Empirically, SARS-CoV-2 in patient nasal swab samples was detected within two minutes, if an extracted FOM threshold of >1 was achieved; otherwise, the sample wasconsidered negative.
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