Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases

Article Peripheral Vascular Disease

Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study

Kazuki Shiina et al.

Summary: This study analyzed the long-term effects of febuxostat on atherosclerosis and arterial stiffness. The results showed that febuxostat treatment group had greater decrease in arterial stiffness parameters and serum uric acid compared to the control group. Therefore, long-term treatment with febuxostat may have beneficial effects on arterial stiffness without improving carotid atherosclerosis.

HYPERTENSION RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Effects of intensive urate lowering therapy with febuxostat in comparison with allopurinol on pulse wave velocity in patients with gout and increased cardiovascular risk: the FORWARD study

Giovambattista Desideri et al.

Summary: The study aimed to compare the effects of febuxostat and allopurinol on carotid-femoral pulse wave velocity in patients with gout and elevated serum uric acid levels. The findings showed that febuxostat was more effective than allopurinol in achieving the SUA target, and both treatments were safe and well tolerated in patients with gout and elevated SUA levels.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2022)

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Article Peripheral Vascular Disease

Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia

Kazuomi Kario et al.

Summary: Both topiroxostat and febuxostat did not have significant effects on arterial stiffness in hypertensive patients with hyperuricemia over 24 weeks of treatment. However, they were effective in reducing serum uric acid levels and blood pressure.

JOURNAL OF CLINICAL HYPERTENSION (2021)

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Article Environmental Sciences

Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population

Yuka Kotozaki et al.

Summary: The study investigated the association between xanthine oxidoreductase (XOR) activity and cardiovascular disease (CVD) risk in a general Japanese population. Results showed that high XOR activity was independently associated with increased risk for CVD and may serve as an indicator for cardiovascular risk in the population.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Biochemistry & Molecular Biology

Xanthine oxidoreductase: A leading actor in cardiovascular disease drama

Letizia Polito et al.

Summary: Cardiovascular diseases are mainly caused by atherosclerosis and are closely linked to oxidative stress and inflammation. Excessive XOR products contribute to inflammatory response and plaque development, increasing the risk of cardiovascular diseases.

REDOX BIOLOGY (2021)

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Article Rheumatology