4.1 Article

The spectrum of kidney biopsy findings in Chinese HIV-infected patients

Journal

HIV MEDICINE
Volume 23, Issue -, Pages 23-31

Publisher

WILEY
DOI: 10.1111/hiv.13246

Keywords

Chinese; highly active anti-retroviral therapy; HIV-1; kidney disease; pathology

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This study retrospectively analyzed renal biopsy results of HIV patients in China and found that classic HIV-associated nephropathy (HIVAN) was uncommon, while HIV immune complex kidney (HIVICK) diseases such as membranous nephropathy or IgA nephropathy were more common and had better prognosis. Antiretroviral therapy, ACE inhibitors, and angiotensin II receptor blockers were effective in reducing proteinuria and preserving renal function.
Objectives HIV-associated kidney disease is common but data on the pathology spectrum of kidney biopsy in China is lacking. This study aimed to illustrate the clinical presentation, laboratory findings and pathological spectrum of different subtypes of HIV-associated kidney disease in China. Methods Eighteen HIV patients with renal biopsy indications at the Peking Union Medical College Hospital from January 2002 to October 2021 were retrospectively enrolled. All had CD4 counts and HIV viral load measurements. Renal biopsies were examined with light microscopy, immunofluorescence, and electron microscopy. Shapiro-Wilk test was used to test whether the data was normally distributed. The data is presented as medians (interquartile range), number (%), or means (+/- SD) according to their distribution. Results Seventeen patients had glomerular disease, and one patient had interstitial nephritis. Membranous nephropathy was present in eight patients (47.1%), and IgA nephropathy in four patients (23.5%). The difference in urine protein and serum albumin before and after treatment was statistically significant and no deaths or dialysis were observed to the end of follow-up. Conclusion This study found that classic HIV-associated nephropathy (HIVAN) was uncommon in Chinese HIV patients. HIV immune complex kidney (HIVICK) disease, such as membranous or IgA nephropathy, was more common, and associated with better prognosis. Antiretroviral therapy, ACE inhibitors, and angiotensin II receptor blockers were effective in decreasing proteinuria and preserving renal function. The use of corticosteroids and immunosuppressive agents seems safe. However, the nephrotoxic effect of antiretroviral agents and other medications should be carefully monitored.

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