Journal
HEPATOLOGY RESEARCH
Volume 52, Issue 7, Pages 597-602Publisher
WILEY
DOI: 10.1111/hepr.13766
Keywords
gamma-GTP; autoimmune hepatitis; nationwide survey; relapse
Categories
Funding
- MHLW Research Program on Intractable Hepatobiliary Disease [JPMH20FC1023]
Ask authors/readers for more resources
The aim of this study was to identify the risk factors for relapse in recently diagnosed AIH patients. The results showed that elevated gamma-GTP levels and liver cirrhosis at diagnosis were significantly associated with relapse.
Aim: Some autoimmune hepatitis (AIH) patients experience relapse during their clinical course, and some risk factors for relapse have been identified previously using a relatively small sample size. The aim of the present study was to identify the risk factors for relapse in recently diagnosed AIH patients using a nationwide survey in Japan. Methods: The nationwide survey performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017 was re-evaluated. A total of 614 patients who received corticosteroids were enrolled in the present study. Associations between relapse and patients' characteristics at diagnosis were evaluated using logistic regression analysis. Results: Relapse was identified in 143 (23.3%) patients after remission. At the time of diagnosis of the disease, there were significant differences in the gamma-glutamyl transpeptidase (gamma-GTP) level, prevalence of liver cirrhosis, and degree of liver fibrosis, Multivariable logistic regression analysis showed that gamma-GTP elevation and liver cirrhosis were significantly associated with relapse. Conclusion: The gamma-GTP level at diagnosis could help identify AIH patients at higher risk of relapse.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available