Use of BTK inhibitors with special focus on ibrutinib in Waldenstrom macroglobulinemia: An expert panel opinion statement

The pivotal role that ibrutinib plays in the management of Waldenstrom macroglobulinemia (WM) is undisputed but there are ongoing questions regarding its positioning in the therapeutic algorithm of WM as well as in some peculiar clinical situations. A panel of experts from Italy was convened to provide real world recommendations on the use of BTK inhibitors in lymphoproliferative diseases in general, and in patients with WM in particular. This position paper represents the panel's collective analysis, evaluation, and opinions and is made up of a series of questions frequently asked by practicing clinicians and answers based on currently available evidence.

Automated summary

A panel of Italian experts convened to provide real world recommendations on the use of BTK inhibitors in lymphoproliferative diseases, particularly in patients with WM. This position paper represents the collective analysis, evaluation, and opinions of the panel, addressing frequently asked questions by clinicians based on currently available evidence.