Journal
HEART
Volume 109, Issue 1, Pages 10-17Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/heartjnl-2021-320008
Keywords
bicuspid aortic valve; aortic dissection; aortic stenosis; aortic regurgitation; aortic aneurysm
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Bicuspid aortic valve is a common congenital anomaly with various morphological phenotypes and clinical presentations. The use of a unified classification system can help in studying and understanding this condition.
Bicuspid aortic valve (BAV), a common congenital anomaly with various morphological phenotypes, is also characterised by marked heterogeneity in clinical presentations including clinically silent condition with mild valvulo-aortopathy, progressive valvulopathy and complex valvulo-aortopathy with shorter life expectancy. The clinical importance of using a general and unified nosology for BAV is well-accepted by opinion leaders and an international consensus statement has been recently published, which will serve as an important scientific platform for BAV. This review describes the current knowledge of BAV based on clinical studies, addresses several unresolved issues requiring investigators' attention and highlights the necessity of prospective studies with a very long follow-up duration for better appreciation of BAV-associated valvulo-aortopathy. In addition, the progression of valvular calcification in patients with BAV and its potential contribution to development of valvulopathy will be discussed.
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