4.4 Review

How I diagnose and treat chronic myelomonocytic leukemia

Related references

Note: Only part of the references are listed.
Article Medical Laboratory Technology

ELN iMDS flow working group validation of the monocyte assay for chronic myelomonocytic leukemia diagnosis by flow cytometry

Orianne Wagner-Ballon et al.

Summary: This multicenter study demonstrates the robustness of the monocyte assay in distinguishing chronic myelomonocytic leukemia from other causes of monocytosis. It also confirms the possibility of using this assay in bone marrow samples.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2023)

Article Hematology

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You et al.

Summary: Mutations in ASXL1 and NRAS genes are associated with poor prognosis in CMML. These mutations lead to dysregulation of MEK/ERK signaling, overexpression of immune checkpoint ligands, and exhaustion of T cells. Combination of targeted therapy and immunotherapy can improve these abnormalities and prolong the survival of AML patients.

BLOOD (2022)

Article Hematology

Cytokine-like protein 1-induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML

Margaux Sevin et al.

Summary: Mouse models of chronic myeloid malignancies have shown that targeting mature cells disrupts feedback loops in disease expansion. In chronic myelomonocytic leukemia (CMML), monocytes in peripheral blood have reduced apoptosis and rely on MCL1, while the MAPK pathway and CYTL1 play roles in their resistance to death. Inhibiting MCL1 and MAPK together restores apoptosis and reduces expansion of patient-derived xenografts, suggesting a promising approach to slow down CMML progression.

BLOOD (2021)

Article Biochemistry & Molecular Biology

Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial

Daniel J. DeAngelo et al.

Summary: The study evaluated the efficacy and safety of avapritinib in patients with AdvSM. Results showed that avapritinib induced deep and durable responses in patients at the recommended dose, demonstrating good tolerability.

NATURE MEDICINE (2021)

Article Multidisciplinary Sciences

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Ryan M. Carr et al.

Summary: The research focuses on the relationship between proliferative chronic myelomonocytic leukemia (pCMML) and RAS pathway mutations, revealing that RAS mutations lead to a unique gene expression profile enriched in mitotic kinases such as PLK1. The study suggests that inhibiting RAS-driven PLK1 expression could be a viable therapeutic target for pCMML.

NATURE COMMUNICATIONS (2021)

Article Hematology

A prognostic score including mutation profile and clinical features for patients with CMML undergoing stem cell transplantation

Nico Gagelmann et al.

Summary: The study demonstrated that mutation status and clinical presentations impact posttransplant outcomes for newly diagnosed CMML patients, leading to the development of a CMML transplant score predicting survival and nonrelapse mortality. The score showed good performance and accuracy, outperforming existing scores designed for nontransplant settings and enabling significant risk reclassification. The CMML transplant score, incorporating mutation and clinical information, proved to be valuable for personalized counseling in transplant patients.

BLOOD ADVANCES (2021)

Article Hematology

Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes

Emma St Martin et al.

Summary: Germline predisposition syndromes (GPS) are caused by constitutional abnormalities in tumor suppressive and homeostatic genes, leading to an increased risk of neoplasia in affected individuals. This study presented clinical and genomic data on 144 Mayo Clinic patients with GPS, revealing distinct patterns in different subtypes of GPS and the importance of comprehensive management approaches for patients with hematological neoplasms.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Oncology

Integrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic Leukemia

Anthony M. Hunter et al.

Summary: The study demonstrated that ruxolitinib showed clinical efficacy in patients with CMML, and PDX modeling can replicate patient responses seen in clinical trials.

CLINICAL CANCER RESEARCH (2021)

Article Hematology

Chronic Myelomonocytic leukemia: 2020 update on diagnosis, risk stratification and management

Mrinal M. Patnaik et al.

AMERICAN JOURNAL OF HEMATOLOGY (2020)

Article Medicine, General & Internal

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

Pierre Fenaux et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

C. D. DiNardo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Oncology

Systemic Reprogramming of Monocytes in Cancer

Mate Kiss et al.

FRONTIERS IN ONCOLOGY (2020)

Article Education, Scientific Disciplines

Genomics of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes

Mrinal M. Patnaik et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2020)

Review Education, Scientific Disciplines

Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review

Mrinal M. Patnaik et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2020)

Review Multidisciplinary Sciences

Clonal hematopoiesis in human aging and disease

Siddhartha Jaiswal et al.

SCIENCE (2019)

Editorial Material Oncology

FGFR1 rearranged hematological neoplasms - molecularly defined and clinically heterogeneous

Mrinal M. Patnaik et al.

LEUKEMIA & LYMPHOMA (2018)

Letter Hematology

Monocytosis is a powerful and independent predictor of inferior survival in primary myelofibrosis

Ayalew Tefferi et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Article Medicine, General & Internal

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

S. Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Letter Hematology

Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance

Rangit Vallapureddy et al.

AMERICAN JOURNAL OF HEMATOLOGY (2017)

Article Oncology

Age-related mutations and chronic myelomonocytic leukemia

C. C. Mason et al.

LEUKEMIA (2016)

Letter Hematology

Targeted next generation sequencing of PDGFRB rearranged myeloid neoplasms with monocytosis

Mrinal M. Patnaik et al.

AMERICAN JOURNAL OF HEMATOLOGY (2016)

Article Oncology

Eltrombopag Use in Patients With Chronic Myelomonocytic Leukemia (CMML): A Cautionary Tale

Hanadi Ramadan et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2016)

Article Medicine, General & Internal

Chronic Myelomonocytic Leukemia: Focus on Clinical Practice

Mrinal M. Patnaik et al.

MAYO CLINIC PROCEEDINGS (2016)

Article Genetics & Heredity

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

Joseph Saliba et al.

NATURE GENETICS (2015)

Article Hematology

Anemia as the Main Manifestation of Myelodysplastic Syndromes

Valeria Santini

SEMINARS IN HEMATOLOGY (2015)

Article Hematology

Transcription and enhancer profiling in human monocyte subsets

Christian Schmidl et al.

BLOOD (2014)

Article Medicine, General & Internal

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Hematology

FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia

Naval Daver et al.

AMERICAN JOURNAL OF HEMATOLOGY (2013)

Editorial Material Hematology

What is a promonocyte?

Barbara J. Bain

AMERICAN JOURNAL OF HEMATOLOGY (2013)

Article Hematology

Clonal architecture of chronic myelomonocytic leukemias

Raphael Itzykson et al.

BLOOD (2013)

Article Oncology

Prognostic Score Including Gene Mutations in Chronic Myelomonocytic Leukemia

Raphael Itzykson et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Article Hematology

Cytogenetic risk stratification in chronic myelomonocytic leukemia

Esperanza Such et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)