Correlations between clinical parameters of dry eye disease and serologic profiles in Sjogren's syndrome

Purpose To investigate the difference in clinical parameters of dry eye disease (DED) according to the presence of serum anti-La antibodies and evaluate the correlations of autoantibody titers with DED parameters in patients with primary Sjogren's syndrome (pSS). Methods Sixty-two patients diagnosed with pSS according to the 2016 ACR-EULAR classification criteria were classified into two groups depending on the presence of anti-La antibodies: group 1 (anti-Ro positive alone, n=31) and group 2 (both anti-Ro and anti-La positive, n=31). DED parameters (conjunctival and corneal ocular staining score (OSS), tear film break-up time (TBUT), Schirmer I test, lipid layer thickness (LLT), meiboscore, and ocular surface disease index), serum autoantibodies (anti-Ro, anti-La, rheumatoid factor (RF), and antinuclear antibody) and focus score were assessed. Results The DED parameters were not significantly different between the two groups (P> 0.05). The anti-Ro titers, RF-positive rate, and the focus score were significantly higher in group 2 than in group 1 (P = 0.001, P = 0.049, P = 0.001, respectively). The anti-Ro titers had a significant positive correlation with conjunctival OSS (r =0.273, P = 0.033) and the focus score had a positive correlation with LLT and meiboscore (r = - 0.358, P = 0.072; r = 0.379, P = 0.056). Conclusion In this study, anti-Ro titers significantly correlated with conjunctival staining score, whereas anti-La did not statistically correlated with clinical DED parameters in SS. Meanwhile, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La, which suggests that examining anti-La with anti-Ro would be helpful in predicting clinical severities of SS patients.

Automated summary

This study aimed to investigate the impact of serum anti-La antibodies on clinical parameters of dry eye disease (DED) and evaluate the correlation between antibody titers and DED parameters. The results showed a significant correlation between anti-Ro titers and conjunctival staining score, while no statistical correlation was found between anti-La and clinical DED parameters. Additionally, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La.