Journal
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume 260, Issue 7, Pages 2111-2120Publisher
SPRINGER
DOI: 10.1007/s00417-022-05588-8
Keywords
Choriocapillaris flow void; Choroidal thickness; Central serous chorioretinopathy; Optical coherence tomography angiography
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Funding
- Basic Science Research Program through the National Research Foundation of Korea [NRF-2020R1F1A1074898]
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The study investigates the choriocapillaris flow in central serous chorioretinopathy and its relationship with choroidal thickness and choroidal vascularity index. The results suggest that there is a decrease in choriocapillaris flow in acute CSC eyes, especially in the foveal lesion. This finding may be attributed to unmodulated choroidal blood flow.
Purpose To evaluate the choriocapillaris (CC) flow in central serous chorioretinopathy (CSC) and determine the relationship between CC flow void with the choroidal thickness (CT) and choroidal vascularity index (CVI). Methods Retrospective analysis of 20 patients with CSC (40 eyes, including unaffected fellow eyes) and 20 age- and sex-matched controls. After compensation with optical coherence tomography (OCT) en-face structural image, the CC flow void (%) was measured using the phansalkar threshold with a window radius of 3 and 15 pixels. The mean CC flow voids of acute CSC, recovered-acute CSC, unaffected fellow, and control eyes were compared by matched data analysis. A regression analysis was performed on the choroidal parameters (CT and CVI) and CC flow voids. Results The CC flow void had an increasing tendency in the following order: control, fellow, recovered-acute CSC, and acute CSC eyes. Acute/recovered comparison showed a significant P value (0.008) in the foveal lesion. Recovered/fellow and fellow/control presented significant P values regardless of location to fovea (all <0.05). There were significant positive correlations between CT and CC flow void (P < 0.05) in the acute CSC, recovered-acute CSC eyes. Conclusion The CC flow on OCT angiography decreased in acute CSC eyes, especially in the foveal lesion, with a published compensation method. The findings suggest that unmodulated choroidal blood flow contributed to partially reversible diminished CC flow.
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