Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 90, Issue -, Pages 101-118Publisher
ELSEVIER
DOI: 10.1016/j.addr.2015.04.025
Keywords
Toxin; Protein; Peptide; Drug delivery; Targeted therapy; Glioma; Blood-brain barrier
Categories
Funding
- National Basic Research Program of China (973 Program) [2013CB932500]
- National Natural Science Foundation of China [81273458, 81473149, 21272187]
- National Science AMP
- Technology Major Project [2012ZX09304004]
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Protein and peptide toxins offer an invaluable source for the development of actively targeted drug delivery systems. They avidly bind to a variety of cognate receptors, some of which are expressed or even up-regulated in diseased tissues and biological barriers. Protein and peptide toxins or their derivatives can act as ligands to facilitate tissue-or organ-specific accumulation of therapeutics. Some toxins have evolved from a relatively small number of structural frameworks that are particularly suitable for addressing the crucial issues of potency and stability, making them an instrumental source of leads and templates for targeted therapy. The focus of this review is on protein and peptide toxins for the development of targeted drug delivery systems and molecular therapies. We summarize disease- and biological barrier-related toxin receptors, as well as targeted drug delivery strategies inspired by those receptors. The design of new therapeutics based on protein and peptide toxins is also discussed. (C) 2015 Elsevier B.V. All rights reserved.
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