4.7 Article

Genome-wide association study reveals the genetic basis of growth trait in catfish with sexual size

Journal

GENOMICS
Volume 114, Issue 3, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2022.110380

Keywords

GWAS; Sexual size dimorphism; SNP; stat5b; Transgene

Funding

  1. National Natural Science Foundation of China [31902355, 32072958]
  2. Excellent Youth Foundation of Hubei Provincial Natural Science Foundation [2021CFA057]
  3. Foundation of Hubei Hongshan Laboratory [2021hszd020]
  4. China Agriculture Research System of MOF and MARA [CARS-46]
  5. National Key Research & Development Program of China [2018YFD0901201]

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This study used GWAS to identify candidate SNPs and genes related to body length and body weight in yellow catfish. Significant associations were found, and a gene related to sexual size dimorphism was also discovered.
Sexual size dimorphism has been widely observed in a large number of animals including fish species. Genomewide association study (GWAS) is a powerful tool to dissect the genetic basis of complex traits, whereas the sexdifferences in the genomics of animal complex traits have been ignored in the GWAS analysis. Yellow catfish (Pelteobagrus fulvidraco) is an important aquaculture fish in China with significant sexual size dimorphism. In this study, GWAS was conducted to identify candidate SNPs and genes related to body length (BL) and body weight (BW) in 125 female yellow catfish from a breeding population. In total, one BL-related SNP and three BW-related SNPs were identified to be significantly associated with the traits. Besides, one of these SNPs (Chr15:19195072) was shared in both the BW and BL traits in female yellow catfish, which was further validated in 185 male individuals and located on the exon of stat5b gene. Transgenic yellow catfish and zebrafish that expressed yellow catfish stat5b showed increased growth rate and reduction of sexual size dimorphism. These results not only reveal the genetic basis of growth trait and sexual size dimorphism in fish species, but also provide useful information for the marker-assisted breeding in yellow catfish.

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