☆ 4.6 Article

Role of genomics in combating COVID-19 pandemic

GENE (2022)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

GenBank

Eric W. Sayers et al.

Summary: GenBank is a comprehensive public database with over 2.5 billion nucleotide sequences totaling 15.3 trillion base pairs for 504,000 formally described species. Recent updates include resources for SARS-CoV-2 virus data, upcoming changes to GI identifiers, and advice for providing contextual metadata in submissions.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The Ensembl COVID-19 resource: ongoing integration of public SARS-CoV-2 data

Nishadi H. De Silva et al.

Summary: The COVID-19 pandemic has led to widespread use of SARS-CoV-2 genome sequencing for epidemiological tracking and variant identification. The Ensembl COVID-19 browser, the first virus to be included in the Ensembl platform, provides multiple variant sets and annotations from relevant resources for SARS-CoV-2 research.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

PDBe-KB: collaboratively defining the biological context of structural data

Mihaly Varadi et al.

Summary: PDBe-KB is an open collaboration platform that aims to integrate functional and biophysical annotations from world-leading specialist data resources, serving the Protein Data Bank. By developing standardized data exchange formats and integrating functional annotations from partner resources, PDBe-KB aims to place macromolecular structure data in a biological context and provide valuable biological insights.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

DNA Data Bank of Japan (DDBJ) update report 2021

Toshihisa Okido et al.

Summary: The Bioinformation and DDBJ (DNA Data Bank of Japan) Center operates archival databases and provides services for life science researchers, including nucleotide sequences, study information, and other genomic data-related services.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study

Maryam Enayatkhani et al.

Summary: This study utilized bioinformatics approaches to design a novel multi-epitope vaccine against the novel Coronavirus, potentially triggering multiple immune responses. Computational tools were used to validate the biological activities of the vaccine, predict the binding of the protein candidate with Toll-like receptor 4 and HLA-A*11:01, and molecular dynamics simulation was employed to evaluate the stability of the designed fusion protein with the receptors.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei et al.

Summary: Identification of essential host genes for SARS-CoV-2 infection, including ACE2 and Cathepsin L, and the discovery of pro-viral genes and pathways specific to SARS lineage and pan-coronavirus provide potential therapeutic targets and insights into pathogenesis of COVID-19. Small-molecule antagonists of these gene products inhibited SARS-CoV-2 infection across species, highlighting their conserved role in susceptibility to highly pathogenic CoVs.

CELL (2021)

Add to Collection

Article Infectious Diseases

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

Shengli Xia et al.

Summary: The inactivated SARS-CoV-2 vaccine, BBIBP-CorV, demonstrated safety and immunogenicity in two age groups. Humoral responses against SARS-CoV-2 were induced in all vaccine recipients by day 42. A two-dose immunisation with 4 mu g vaccine on days 0 and 21 or days 0 and 28 achieved higher neutralising antibody titres compared to other dosing schedules.

LANCET INFECTIOUS DISEASES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

Wioletta Rut et al.

Summary: A team of researchers synthesized a new type of antiviral agent, demonstrating through experiments its high efficacy in inhibiting SARS-CoV-2 with a low effective concentration, providing new insights for antiviral treatment. By observing the active SARS-CoV-2 M-pro in the cells of patients infected with COVID-19, important clues were provided for the design of antiviral drugs and diagnostic tests.

NATURE CHEMICAL BIOLOGY (2021)

Add to Collection

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

CoV3D: a database of high resolution coronavirus protein structures

Ragul Gowthaman et al.

Summary: CoV3D is a database and resource for coronavirus protein structures, updated weekly, providing users with comprehensive sets of coronavirus protein structures and complexes, with integrated molecular viewers for visualization.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Gene editing and RNAi approaches for COVID-19 diagnostics and therapeutics

Burak Berber et al.

Summary: COVID-19, caused by SARS-CoV-2, presents challenges in surveillance and diagnosis due to limitations in testing capacity, test specificity issues, and the possibility of co-infections with other respiratory viruses. Innovative molecular biology tools are needed to revolutionize diagnostic and therapeutic approaches in fighting COVID-19 and future outbreaks.

GENE THERAPY (2021)

Add to Collection

Article Infectious Diseases

Analysis of the potential impact of genomic variants in global SARS-CoV-2 genomes on molecular diagnostic assays

Abhinav Jain et al.

Summary: The SARS-CoV-2 epidemic originating from Wuhan rapidly evolved into a global pandemic, highlighting the importance of molecular detection using RT-PCR, although mutations in the viral genome could impact the accuracy of detection assays. The analysis of global SARS-CoV-2 genomes identified multiple genetic variants that could affect the effectiveness of diagnostic primers and probes.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Biology

Analysis of 329,942 SARS-CoV-2 records retrieved from GISAID database

Maria Zelenova et al.

Summary: This study examined a large number of SARS-CoV-2 records in the GISAID database, identifying genetic variations and clustering patterns. It investigated the presence of different variants and factors influencing them, analyzed the completeness of the database, and patient characteristics. Results highlighted the variation in different genes, offering multiple avenues for further research in both SARS-CoV-2 studies and health science.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

Add to Collection

Editorial Material Medicine, General & Internal

Oxford-AstraZeneca COVID-19 vaccine efficacy

Maria Deloria Knoll et al.

LANCET (2021)

Add to Collection

News Item Multidisciplinary Sciences

ALARMING COVID VARIANTS SHOW KEY ROLE OF GENOMIC SURVEILLANCE

David Cyranoski

NATURE (2021)

Add to Collection

Article Medicine, General & Internal

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

Carlos Salama et al.

Summary: Among hospitalized patients with Covid-19 pneumonia not on mechanical ventilation, tocilizumab reduced the risk of progression to mechanical ventilation or death, but did not improve overall survival. There were no new safety concerns identified.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

Stephen K. Burley et al.

Summary: RCSB PDB, as the US data center for the global PDB archive, provides free access to 3D macromolecular structure data for millions of users worldwide, including educators, students, and the general public, integrating over 40 external biodata resources. The redesigned website now features improved search functionality and easier access to PDB data, showcasing new structures relevant to the understanding and addressing of the COVID-19 pandemic.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Immunology

Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses

Saathvik R. Kannan et al.

Summary: The study revealed differences in the mutational profile between Delta and Delta Plus variants, with Delta Plus having more high-prevalence mutations and unique signature mutations. Structural analysis showed that these mutations can weaken the interactions between the virus and antibodies.

JOURNAL OF AUTOIMMUNITY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Designing a next generation multi-epitope based peptide vaccine candidate against SARS-CoV-2 using computational approaches

Ratnadeep Saha et al.

Summary: COVID-19 caused by SARS-CoV-2 was declared a global pandemic in March 2020 by WHO. Through studying the Spike glycoprotein, researchers developed a novel MEBP vaccine candidate showing strong immunogenicity.

3 BIOTECH (2021)

Add to Collection

Article Virology

Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread?

Tuna Toptan et al.

Summary: The study evaluated the sensitivity and specificity of a newly licensed rapid antigen test for SARS-CoV-2, showing its effectiveness in detecting infectious patients. The antigen test was found to have no cross-reactivity against other common respiratory viruses and demonstrated reliable performance.

JOURNAL OF CLINICAL VIROLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Denis Y. Logunov et al.

Summary: The Gam-COVID-Vac vaccine showed 91.6% efficacy against COVID-19 in the phase 3 trial, with good safety and tolerability in a large cohort of participants.

LANCET (2021)

Add to Collection

Article Medicine, General & Internal

Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial

Peter Richmond et al.

Summary: A study in Australia evaluated the dose-finding and adjuvant justification of the SCB-2019 vaccine against SARS-CoV-2. The vaccine, which contains a stabilised trimeric form of the spike protein (S-Trimer) combined with AS03 or CpG/Alum adjuvants, elicited robust humoral and cellular immune responses in both younger and older adults.

LANCET (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The SARS-CoV-2 subgenome landscape and its novel regulatory features

Dehe Wang et al.

Summary: Through next-generation sequencing, it was found that SARS-CoV-2 can generate diverse subgenomes through template switching. The majority of template switches result from RNA-RNA interactions, with terminal pairing status playing a key role.

MOLECULAR CELL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses

Nicola Borbone et al.

Summary: Coronaviruses are a family of enveloped RNA viruses that cause a wide range of respiratory infections in mammals, including humans. Three human CoV species have led to severe respiratory diseases such as SARS, MERS, and the current COVID-19 pandemic. The emergence of SARS-CoV-2 in late 2019 has resulted in a global public health crisis, highlighting the urgent need for effective drugs to combat the infection. The repurposing of nucleoside derivatives is a promising strategy for quickly developing therapies against SARS-CoV-2 and other HCoV species.

MOLECULES (2021)

Add to Collection

Letter Biotechnology & Applied Microbiology

Could mutations of SARS-CoV-2 suppress diagnostic detection?

Carl A. Ascoli

NATURE BIOTECHNOLOGY (2021)

Add to Collection

Article Genetics & Heredity

Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2

Jim Baggen et al.

Summary: Genome-wide CRISPR screens have revealed that the lysosomal protein TMEM106B is essential for SARS-CoV-2 infection. Overexpression of TMEM106B enhances both SARS-CoV-2 and pseudovirus infection, indicating a potential role in viral entry. Single-cell RNA-sequencing data from COVID-19 patient airway cells shows a correlation between TMEM106B expression and SARS-CoV-2 infection.

NATURE GENETICS (2021)

Add to Collection

Article Multidisciplinary Sciences

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

Nicholas G. Davies et al.

Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.

SCIENCE (2021)

Add to Collection

Article Virology

Phylogenetic reconstruction of the initial stages of the spread of the SARS-CoV-2 virus in the Eurasian and American continents by analyzing genomic data

Yu. S. Bukin et al.

Summary: Analysis of complete genomes of SARS-CoV-2 from 21 countries during the first wave of the COVID-19 pandemic revealed that the virus first appeared in humans in China between July and November 2019, spreading to other countries in autumn 2019, and being present in all analyzed countries by mid-February 2020. The global population of SARS-CoV-2 showed low levels of genetic polymorphism during this time, making it difficult to accurately assess infection pathways. The evolutionary rate of the SARS-CoV-2 genome was comparable to that of other human RNA viruses, and it was separated from its closest known relative, the bat coronavirus RaTG13, approximately 15-43 years ago.

VIRUS RESEARCH (2021)

Add to Collection

Article Multidisciplinary Sciences

Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation

Brunda Ganneru et al.

Summary: The study reports the development and evaluation of a whole virion inactivated COVID-19 vaccine, showing high antigen-binding and neutralizing antibody titers in mice, rats, and rabbits, with excellent safety profiles.

ISCIENCE (2021)

Add to Collection

Article Biology

SARS-CoV-2 Molecular Transmission Clusters and Containment Measures in Ten European Regions during the First Pandemic Wave

Maria Bousali et al.

Summary: The use of viral genomic data for spatiotemporal profiling of SARS-CoV-2 MTCs can effectively identify transmission networks, with variations in MTC scale and age distribution across different regions. Monitoring the spatiotemporal distribution of MTCs can help evaluate the effectiveness of interventions.

LIFE-BASEL (2021)

Add to Collection

Article Immunology

Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Yassir A. Almofti et al.

Summary: A novel vaccine construct against SARS-CoV-2 was designed from spike S protein and orf1ab polyprotein, showing potential protection against the pandemic. This study may assist in developing a suitable therapeutics protocol to combat SARSCoV-2 infection.

BMC IMMUNOLOGY (2021)

Add to Collection

Article Immunology

INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

Viviane M. Andrade et al.

Summary: Global surveillance has identified emerging SARS-CoV-2 variants of concern with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. In this study, individuals vaccinated with the DNA vaccine INO-4800 showed neutralizing antibodies against all tested variants, although levels were reduced against B.1.351. IFN gamma T cell responses remained fully maintained against all variants tested.

NPJ VACCINES (2021)

Add to Collection

Editorial Material Virology

Bioinformatics and immunoinformatics to support COVID-19 vaccine development

Stephanie Ishack et al.

Summary: The rapid spread of SARS-CoV-2 has resulted in a high number of infections and deaths, highlighting the urgent need for more rapid and precise vaccine design using computational methods.

JOURNAL OF MEDICAL VIROLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Tocilizumab in COVID-19: some clarity amid controversy

Shruti Gupta et al.

LANCET (2021)

Add to Collection

Article Medicine, General & Internal

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J. Haas et al.

Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.

LANCET (2021)

Add to Collection

Article Infectious Diseases

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials

Shilong Yang et al.

Summary: The results from Phase 1 and Phase 2 trials of the COVID-19 vaccine ZF2001 show that the vaccine is well tolerated and immunogenic, supporting the use of a 25 microgram dose in a three-dose schedule for large-scale evaluation in a Phase 3 trial.

LANCET INFECTIOUS DISEASES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

Brian J. Ward et al.

Summary: This study reported the interim safety and immunogenicity data of a plant-produced COVID-19 vaccine candidate at Day 42. The results showed good tolerability of all formulations and induction of immune responses, supporting further evaluation of the vaccine candidate.

NATURE MEDICINE (2021)

Add to Collection

Review Genetics & Heredity

Testing at scale during the COVID-19 pandemic

Tim R. Mercer et al.

Summary: The assembly and publication of the SARS-CoV-2 genome in January 2020 allowed for immediate development of tests and led to the largest global testing programme in history. Despite efforts to control the spread, widespread community transmission of the virus has become entrenched in many countries, necessitating population-scale testing to identify and isolate infected individuals. Testing plays a crucial role in the response to the COVID-19 pandemic and is likely to continue to be vital in public health.

NATURE REVIEWS GENETICS (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

Pramod R. Bhatt et al.

Summary: This study revealed the key event of programmed ribosomal frameshifting during translation of SARS-CoV-2, validated the importance of frameshifting for viral RNA synthesis through structural observations and biochemical experiments, and identified mechanistic and regulatory features influencing frameshifting efficiency.

SCIENCE (2021)

Add to Collection

Article Virology

Identification of Epidemiological Traits by Analysis of SARS-CoV-2 Sequences

Bohu Pan et al.

Summary: The transmission of SARS-CoV-2 is primarily through person-to-person contact, and phylogenetic analysis revealed a co-expansion tendency of the virus among neighboring countries. Pairwise sequence similarity analysis showed that SARS-CoV-2 is transmitted locally and evolves during transmission, with no significant differences in genomes grouped by host age or sex.

VIRUSES-BASEL (2021)

Add to Collection

Article Multidisciplinary Sciences

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

Jean-Selim Driouich et al.

Summary: Despite limited pre-clinical evidence, repurposed drugs such as favipiravir are being extensively evaluated in clinical trials to combat the lack of antiviral options against SARS-CoV-2. Favipiravir shows strong antiviral efficacy in a Syrian hamster model, with high doses reducing viral infectivity while inducing mutations in viral genomes. However, toxicity concerns are noted at the highest tested dose, requiring further pharmacokinetic and tolerance studies before potential human use.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Multidisciplinary Sciences

Prioritizing antiviral drugs against SARS-CoV-2 by integrating viral complete genome sequences and drug chemical structures

Lihong Peng et al.

Summary: The outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 has drawn global attention, emphasizing the importance of prioritizing approved drugs for quick clinical trials. By utilizing a Random Walk with Restart method, possible Virus-Drug Associations related to SARS-CoV-2 were successfully identified, outperforming other prediction models in the study. Additionally, experimental results showed potential for the use of navitoclax in combating SARS-CoV-2, warranting further validation.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

Analysis of SARS-CoV-2 genomic epidemiology reveals disease transmission coupled to variant emergence and allelic variation

D. J. Darwin R. Bandoy et al.

Summary: The study identified the speed and characteristics of the global spread of the novel coronavirus, proposing a method based on genomic variation and epidemiological data to predict increases in cases. By exploring differences in transmission between countries, researchers discovered variations in viral transmission dynamics across different nations and epidemic stages.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Food Science & Technology

SARS-CoV-2 inactivated vaccine (Vero cells) shows good safety in repeated administration toxicity test of Sprague Dawley rats

Zhangqiong Huang et al.

Summary: The study aimed to evaluate the toxicity and severity of an inactivated SARS-CoV-2 vaccine in Sprague Dawley rats after multiple injections. Results showed no evident toxic reactions, stimulation of neutralizing antibodies, and overall safety of the vaccine in the rats.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults A Randomized Clinical Trial

Nawal Al Kaabi et al.

Summary: This interim analysis of an ongoing randomized trial in the UAE and Bahrain evaluated the efficacy of two inactivated COVID-19 vaccines in preventing symptomatic cases and adverse events in healthy adults. The study found that both vaccines significantly reduced the risk of symptomatic COVID-19 compared to the control group, with efficacy rates of 72.8% and 78.1%. Serious adverse events were rare across all groups.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Medicine, General & Internal

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Mine Durusu Tanriover et al.

Summary: The study presented the interim efficacy and safety results of the CoronaVac vaccine in a phase 3 clinical trial in Turkey, demonstrating high efficacy against PCR-confirmed symptomatic COVID-19 with good safety and tolerability profile. Results showed significant differences in the frequency of any adverse events between the vaccine and placebo groups, indicating excellent protective effects of the vaccine.

LANCET (2021)

Add to Collection

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

Shipo Wu et al.

Summary: The study evaluated the safety and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine in adults without COVID-19 from China. It found that the aerosol vaccine was well tolerated, and two doses elicited neutralising antibody responses similar to one dose of intramuscular injection. An aerosolised booster vaccination at 28 days after the first intramuscular injection induced strong IgG and neutralising antibody responses. The efficacy and cost-effectiveness of aerosol vaccination should be evaluated in future studies.

LANCET INFECTIOUS DISEASES (2021)

Add to Collection

Article Multidisciplinary Sciences

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

Galit Alter et al.

Summary: The Ad26.COV2.S vaccine has shown clinical efficacy against symptomatic COVID-19, including the B.1.351 variant, but there is uncertainty regarding its immunogenicity against SARS-CoV-2 variants. The study found that neutralizing antibody responses were reduced against the B.1.351 and P.1 variants, while non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants.

NATURE (2021)

Add to Collection

News Item Multidisciplinary Sciences

INDIA'S DNA COVID VACCINE IS A WORLD FIRST - MORE ARE COMING

Smriti Mallapaty

NATURE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis

Angela Choi et al.

Summary: The study demonstrates that both the mRNA-1273 COVID-19 vaccine and its variant-modified booster doses are safe and effective in improving neutralizing antibody titers against various virus variants.

NATURE MEDICINE (2021)

Add to Collection

Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

Paul T. Heath et al.

Summary: The NVX-CoV2373 vaccine demonstrated an efficacy of 89.7% in a phase 3 trial with over 15,000 participants, with mild and transient reactogenicity. It showed high efficacy against the B.1.1.7 variant and a low incidence of adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The COVID-19 Data Portal: accelerating SARS-CoV-2 and COVID-19 research through rapid open access data sharing

Peter W. Harrison et al.

Summary: The global outbreak of SARS-CoV-2 has resulted in significant impacts on human society and millions of deaths. The COVID-19 Data Portal aims to accelerate global research by providing open data sharing and analysis services.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Editorial Material Microbiology

SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse

Frank Konings et al.

Summary: A group convened and led by the Virus Evolution Working Group of the World Health Organization has announced a naming scheme to enable clear communication about SARS-CoV-2 variants of interest and concern.

NATURE MICROBIOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Safety and immunogenicity of a QazCovid-in® inactivated whole-virion vaccine against COVID-19 in healthy adults: A single-centre, randomised, single-blind, placebo-controlled phase 1 and an open-label phase 2 clinical trials with a 6 months follow-up in Kazakhstan

Kunsulu Zakarya et al.

Summary: The QazCovid-in (R) vaccine, developed in Kazakhstan, showed good safety and tolerability in phase 1 and 2 clinical trials, inducing significant immune response that lasts at least 6 months.

ECLINICALMEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

Safety and immunogenicity of a Recombinant Stabilized Prefusion SARS-CoV-2 Spike Protein Vaccine (MVC-COV1901) Adjuvanted with CpG 1018 and Aluminum Hydroxide in healthy adults: A Phase 1, dose-escalation study

Szu-Min Hsieh et al.

Summary: The MVC-COV1901 vaccine was well tolerated and elicited robust immune responses, making it suitable for further development.

ECLINICALMEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India

Taufik Momin et al.

Summary: The Phase 1 trial of ZyCoV-D DNA vaccine conducted in India showed that the vaccine is safe, well-tolerated, and immunogenic, warranting further investigation.

ECLINICALMEDICINE (2021)

Add to Collection

Article Virology

Genomic epidemiology of a densely sampled COVID-19 outbreak in China

Lily Geidelberg et al.

Summary: Genetic sequence data analysis from a relatively small and geographically constrained outbreak in Weifang, China, provided insights into the epidemic's characteristics. Bayesian model-based phylodynamic methods estimated the mean basic and effective reproduction numbers in the region. The study concluded that estimated infections were consistent with reported cases and there was unlikely to be a large undiagnosed burden of infections during the studied period.

VIRUS EVOLUTION (2021)

Add to Collection

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

Add to Collection

Article Virology

Genomic epidemiology of a densely sampled COVID-19 outbreak in China

Lily Geidelberg et al.

Summary: Genetic sequence data analysis of the SARS-CoV-2 pandemic provides insights into epidemic origins and spread patterns. In the Weifang outbreak, the mean basic reproduction number (R-0) was estimated at 3.4, with the mean effective reproduction number (R-t) falling below 1 before February 4. The estimated number of infections aligns with confirmed cases, indicating a low undiagnosed burden of infection during the study period.

VIRUS EVOLUTION (2021)

Add to Collection

Editorial Material Cell Biology

Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses

Tuan M. Nguyen et al.

CELL RESEARCH (2020)

Add to Collection

Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

Add to Collection

Article Medicine, General & Internal

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Roujian Lu et al.

LANCET (2020)

Add to Collection

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Add to Collection

Editorial Material Biotechnology & Applied Microbiology

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

Guangdi Li et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Add to Collection

Article Medicine, General & Internal

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Qun Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Add to Collection

Article Microbiology

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Michael Letko et al.

NATURE MICROBIOLOGY (2020)

Add to Collection

Review Pharmacology & Pharmacy

Recent advances and perspectives of nucleic acid detection for coronavirus

Minzhe Shen et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

Timothy R. Abbott et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States

Joseph R. Fauver et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

Add to Collection

Editorial Material Pathology

Real-time RT-PCR in COVID-19 detection: issues affecting the results

Alireza Tahamtan et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2020)

Add to Collection

Article Immunology

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

Jasper Fuk-Woo Chan et al.

EMERGING MICROBES & INFECTIONS (2020)

Add to Collection

Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Microbiology

Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?

Ping Liu et al.

PLOS PATHOGENS (2020)

Add to Collection

Article Medicine, General & Internal

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

Feng-Cai Zhu et al.

LANCET (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Assay Techniques and Test Development for COVID-19 Diagnosis

Linda J. Carter et al.

ACS CENTRAL SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Kangpeng Xiao et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Tommy Tsan-Yuk Lam et al.

NATURE (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

CRISPR-Cas12-based detection of SARS-CoV-2

James P. Broughton et al.

NATURE BIOTECHNOLOGY (2020)

Add to Collection

Letter Biochemistry & Molecular Biology

The proximal origin of SARS-CoV-2

Kristian G. Andersen et al.

NATURE MEDICINE (2020)

Add to Collection

Letter Virology

Computational Identification of Small Interfering RNA Targets in SARS-CoV-2

Wei Chen et al.

VIROLOGICA SINICA (2020)

Add to Collection

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Medical Laboratory Technology

Highly sensitive detection of SARS-CoV-2 RNA by multiplex rRT-PCR for molecular diagnosis of COVID-19 by clinical laboratories

Takayuki Ishige et al.

CLINICA CHIMICA ACTA (2020)

Add to Collection

Review Infectious Diseases

Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results

G. Caruana et al.

CLINICAL MICROBIOLOGY AND INFECTION (2020)

Add to Collection

Review Infectious Diseases

The genetic sequence, origin, and diagnosis of SARS-CoV-2

Huihui Wang et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Bette Korber et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A Thermostable mRNA Vaccine against COVID-19

Na-Na Zhang et al.

CELL (2020)

Add to Collection

Article Immunology

COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning

Edison Ong et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Presence of mismatches between diagnostic PCR assays and coronavirus SARS-CoV-2 genome

Kashif Aziz Khan et al.

ROYAL SOCIETY OPEN SCIENCE (2020)

Add to Collection

Article Microbiology

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

Maciej F. Boni et al.

NATURE MICROBIOLOGY (2020)

Add to Collection

Article Medicine, Research & Experimental

Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study

Abdo A. Elfiky

LIFE SCIENCES (2020)

Add to Collection

Review Chemistry, Medicinal

Genomics insights of SARS-CoV-2 (COVID-19) into target-based drug discovery

P. Chellapandi et al.

MEDICINAL CHEMISTRY RESEARCH (2020)

Add to Collection

Article Multidisciplinary Sciences

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Laura Riva et al.

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling

Rebecca J. Rockett et al.

NATURE MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands

Bas B. Oude Munnink et al.

NATURE MEDICINE (2020)

Add to Collection

Editorial Material Microbiology

GENOME WATCH Genomics and epidemiological surveillance

Stephanie W. Lo et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California

Xianding Deng et al.

SCIENCE (2020)

Add to Collection

Article Infectious Diseases

Emergence of genomic diversity and recurrent mutations in SARS-CoV-2

Lucy van Dorp et al.

INFECTION GENETICS AND EVOLUTION (2020)

Add to Collection

Article Infectious Diseases

Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: A computational biology approach

Syed Mohammad Lokman et al.

INFECTION GENETICS AND EVOLUTION (2020)

Add to Collection

Article Biochemistry & Molecular Biology

High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment

Biswajit Naik et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection

Review Multidisciplinary Sciences

SARS-CoV-2 vaccines in development

Florian Krammer

NATURE (2020)

Add to Collection

Article Medicine, General & Internal

Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

Cheryl Keech et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Tracking the COVID-19 pandemic in Australia using genomics

Torsten Seemann et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Infectious Diseases

Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2

Muhammad Tahir ul Qamar et al.

INFECTIOUS DISEASES OF POVERTY (2020)

Add to Collection

Article Immunology

A Distinct Phylogenetic Cluster of Indian Severe Acute Respiratory Syndrome Coronavirus 2 Isolates

Sofia Banu et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

Add to Collection

Review Microbiology

Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients

Reza Ghanbari et al.

FUTURE MICROBIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Design of a multi-epitope vaccine against SARS-CoV-2 using immunoinformatics approach

Samira Sanami et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection

Editorial Material Medicine, General & Internal

FDA Approval of Remdesivir - A Step in the Right Direction

Daniel Rubin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Virology

Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a

Khajohn Joonlasak et al.

VIRUS RESEARCH (2020)

Add to Collection

Article Multidisciplinary Sciences

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

Matthew S. Buckland et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Genetics & Heredity

The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR

Shuhui Song et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Probing antiviral drugs against SARS-CoV-2 through virus-drug association prediction based on the KATZ method

Liqian Zhou et al.

GENOMICS (2020)

Add to Collection

Letter Zoology

An online coronavirus analysis platform from the National Genomics Data Center

Zheng Gong et al.

ZOOLOGICAL RESEARCH (2020)

Add to Collection

Review Immunology

CRISPR-Cas System: An Approach With Potentials for COVID-19 Diagnosis and Therapeutics

Prashant Kumar et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel

Danielle Miller et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Editorial Material Infectious Diseases

GISAID: Global initiative on sharing all influenza data - from vision to reality

Yuelong Shu et al.

EUROSURVEILLANCE (2017)

Add to Collection

Article Genetics & Heredity

Assessing multilevel determinants of adoption and implementation of genomic medicine: an organizational mixed-methods approach

Sabine M. Oishi et al.

GENETICS IN MEDICINE (2015)

Add to Collection

© Peeref 2019-2024. All rights reserved.