New kinase and HDAC hybrid inhibitors: recent advances and perspectives

Cancer is the second most common cause of death worldwide. It can easily acquire resistance to treatments, demanding new therapeutic strategies, such as simultaneous inhibition of kinase and HDAC enzymes with hybrid inhibitors. Different approaches to this have varied according to their targets, with a few common trends, such as the usage of heterocycle scaffolds for kinase interaction, especially pyrimidine and quinazolines, and hydroxamic acids and benzamides for HDAC inhibition. Besides the hybrid compounds developed focusing on the inhibition tyrosine kinase and receptor tyrosine kinase, many advances have occurred in the development of serine-threonine kinase/HDAC and lipid kinase/HDAC novel compounds. Here, the latest strategies employed in this research area will be reviewed, alongside trends in inhibitor design, and observed gaps will be punctuated.

Automated summary

Cancer resistance to treatments is a major challenge and the development of new therapeutic strategies is needed. Inhibitors that simultaneously target kinases and HDAC enzymes have been explored using various approaches, including specific compounds and heterocycle scaffolds. Advances have also been made in developing novel compounds to inhibit other types of kinases and HDAC enzymes.