Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 187, Issue -, Pages 141-157Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2022.05.018
Keywords
Silibinin; Sepsis; Septic myocardial injury; Pretreatment; Posttreatment
Funding
- National Natural Science Foundation of China [81871607, 82070422]
- Natural Science Foundation of Shaanxi Province [2020JM-386, 2018JM3042]
- Innovation Capability Strong Foundation Plan of Xi'an City(Medical Research Project) [21YXYJ0037]
Ask authors/readers for more resources
Silibinin (SIL) has a protective effect on sepsis and septic myocardial injury by inhibiting inflammation, oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the NR1H3 pathway.
Cardiac dysfunction resulting from sepsis causes high morbidity and mortality. Silibinin (SIL) is a secondary metabolite isolated from the seed extract of the milk thistle plant with various properties, including antiinflammatory, anti-fibrotic, and anti-oxidative activities. This study, for the first time, examined the effects and mechanisms of SIL pretreatment, posttreatment and in combination with classical antibiotics in septic myocardial injury. The survival rate, sepsis score, anal temperature, routine blood parameters, blood biochemical parameters, cardiac function indicators, pathological indicators of myocardial injury, NR1H3 signaling pathway, and several sepsis-related signaling pathways were detected 8 h following cecal ligation and puncture (CLP). Our results showed that SIL pretreatment showed a significant protective effect on sepsis and septic myocardial injury, which was explained by the attenuation of inflammation, inhibition of oxidative stress, improvement of mitochondrial function, regulation of endoplasmic reticulum stress (ERS), and activation of the NR1H3 pathway. SIL posttreatment and the combination of SIL and azithromycin (AZI) showed a certain therapeutic effect. RNA-seq detection further clarified the myocardial protective mechanisms of SIL. Taken together, this study provides a theoretical basis for the application strategy and combination of SIL in septic myocardial injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available