Inhibition of Pro-Inflammatory Cytokine Secretion by Polyphenol-Rich Extracts in Macrophages via NF-κB Pathway

Macrophages play important roles in acute and chronic inflammation. Upon their activation, they secrete a variety of mediators, including cytokines, which are involved in the inflammatory response. Polyphenols are a wide group of compounds with many health-promoting properties. They are characterized by antioxidant, anti-cancer and anti-inflammatory activity. Numerous studies conducted on single phenols shed light on plant extracts rich in these compounds. The aim of this descriptive review is to demonstrate the anti-inflammatory role of phenol-rich natural extracts by modulating the NF-kappa B signaling pathway in macrophage cells. Additionally, this article focuses on the influence of phenolic extracts on the inhibition of proinflammatory cytokines, such as IL-1 beta, IL-6, TNF-alpha. The cited studies prove that plant extracts possess anti-inflammatory activity, and due to the wide role of inflammation in various diseases, from cardiovascular diseases to cancer, they can be used as therapeutic agents. What's more, increasing awareness in the area of proper nutrition and consumption of food rich in polyphenols may have a protective effect on human health.

Automated summary

This article reviews the anti-inflammatory role of phenol-rich natural extracts, particularly in modulating the NF-kappa B signaling pathway and inhibiting proinflammatory cytokines. Plant extracts have anti-inflammatory activity and can be used as therapeutic agents in various diseases. Additionally, consuming food rich in polyphenols may have a protective effect on human health.