Journal
FOOD RESEARCH INTERNATIONAL
Volume 153, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2022.110945
Keywords
Licorice extract; Type 2 diabetes; Gut microbiota; TLR4/NF-kappa B signaling pathway
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Funding
- National Key Research and Develop-ment Program of China [2021YFE0110000]
- National Natural Sci-ence Foundation of China [31501475]
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Licorice extract improves blood glucose levels and metabolic functions in type 2 diabetic mice by regulating the gut microbiota and colon signaling pathway.
Previous studies suggested that licorice possessed hypoglycemic activity, but its anti-diabetic mechanism has not been clearly illustrated. Herein, we aimed to investigate the hypoglycemic activity and underlying hypoglycemic mechanisms of licorice extract (20, 40, and 80 mg kg(-1) day(-1)) in type 2 diabetes mice. The results showed that licorice extract could improve the levels of fasting blood glucose, insulin resistance, serum lipids, and endotoxemia-related colonic inflammation in diabetic mice in a dose-dependent manner. Western blots also suggested that a high-dose licorice extract could effectively decrease the levels of nuclear factor kappa-B (NF-kappa B), toll-like receptor 4 (TLR4), and tumor necrosis factor-alpha (TNF-alpha) in colon of diabetic mice. More importantly, all the doses of licorice extract reshaped the gut microbiota by decreasing the contents of Lachnospiraceae_ NK4A136 _group at the genus level and increasing the contents of Alloprevotella, Baceroides, and Akkermansia, especially for the high-dose of licorice extract. These results indicated that the anti-diabetic effect of licorice extract might be attributed to the regulation of the gut microbiota and the colon TLR4/NF-kappa B signaling pathway in diabetic mice. Thus, licorice extract can be a promising dietary agent to improve type 2 diabetes.
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