Journal
FOOD HYDROCOLLOIDS
Volume 124, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2021.107290
Keywords
Human milk; Infant formula; Interfacial composition; Fat globule structure; Milk fat globule membrane
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Funding
- Major projects in dairy products and meat processing technology [2019ZX07B01]
- Chinese Institute of Food Science and Technology-Abbott Food Nutrition and Safety Special Scientific Research Fund [2020-01]
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The study analyzed and compared fat globule interfacial compositions and structures in human milk and three types of infant formulas (IF1, IF2, IF3). While IF1 was closer to human milk in terms of interfacial protein composition, it still lacked certain important bioactive proteins. Differences were also found in interfacial phospholipids between human milk and infant formulas, with IF1 having the closest composition. However, the study concluded that despite the inclusion of MFGM, infant formulas did not replicate the fat globule structures found in human milk.
In this study, we analyzed and compared the fat globule interfacial compositions and structures in human milk and three types of infant formulas (IF1: supplied with MFGM, IF2: without MFGM and soy lecithin, IF3: supplied with soy lecithin). The results suggested that the interfacial protein composition of IF1 was comparatively closer to human milk, but still lacked certain bioactive MFGM proteins including XO, ADPH and PAS6/7. Considering the interfacial phospholipid, we observed 23, 31, and 29 phospholipid species that could be used to distinguish human milk and infant formulas (IF1, IF2 and IF3). We also found that phosphatidylinositol (PI) and phosphatidylserine (PS), which can absorb lipase, phosphatidylethanolamine (PE), and phosphatidylcholine (PC) and connect functional fatty acids, were lacking in infant formulas. Moreover, the infant formulas had a smaller average particle size of 0.38 mu m and a thicker interfacial layer that interacted with the casein micelles. Even if IF1 included MFGM, fat globules structures like those found in human milk did not form, and the majority of the MFGM was still in the aqueous phase in free form. Overall, the comprehensive analysis in this study could be used to simulate or mimic human milk lipids at the supramolecular level.
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