Journal
FOOD CONTROL
Volume 133, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodcont.2021.108629
Keywords
Violacein; Virulence factor; Acyl-homoserine lactone; Motility; Molecular docking
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Funding
- Science and Technology Program of Jiangsu Province [BE2019355]
- National Natural Science Foundation of China [31501460]
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The study found that soybean isoflavones as a quorum sensing inhibitor exhibit significant inhibitory effects on violacein production, biofilm formation, motility, and virulence factor production in Pseudomonas aeruginosa. Molecular docking analysis revealed a competitive interaction between soybean isoflavones and acyl-homoserine lactones.
The potential of soybean isoflavones (SI) as a quorum sensing (QS) inhibitor against Pseudomonas aeruginosa was investigated in the present study. The inhibitory effects of SI on violacein production, biofilm formation, motility, and virulence factor production were evaluated. The acyl-homoserine lactones (AHLs) were quantified by liquid chromatography-mass spectrometry (LC-MS). The QS-related genes were analyzed by qRT-PCR. The molecular docking analysis was employed to investigate the anti-QS mechanism of the SI. Results demonstrated that the SI exhibited significant inhibition (p < 0.05) in violacein production, biofilm formation, motility, virulence factors, AHLs production, and expression levels of QS-related genes in P. aeruginosa. Additionally, the result of molecular docking analysis revealed that SI had a promising competitive interaction with AHLs. Hence, the study provided a deep insight into SI as a QS inhibitor against P. aeruginosa.
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