Study on the digestive characteristics of short-and medium-chain fatty acid structural lipid and its rapid intervention on gut microbes: In vivo and in vitro studies

Structuring is a feasible scheme to improve lipids' value. Here, S-BL and S-LBL (C4-C12 structural lipids) were obtained through enzymatic ester-ester transesterification or acidolysis interesterification using glyceryl tributyrate/glyceryl tridodecanoate and lauric acid/glyceryl tributyrate as raw materials, respectively. The digestive characteristics of S(BL & nbsp;)and S-LBL were investigated in vitro and in vivo, meanwhile, their effects on gut microbes were studied. Compared with their corresponding triglyceride physical mixture, S(BL & nbsp;)possessed an ideal butyric acid sustained-release effect in simulated stomach digestion. Moreover, the sustained-release effect of S-LBL on glycerol monolaurate (GML) was revealed both in vivo and in vitro, while this effect of the S-BL & nbsp;was obviously occurred in small intestine. S(BL & nbsp;)significantly increased the abundance of Bifidobacterium and S-LBL promoted the growth of Clostridiales within 24 h. Overall, both S-BL & nbsp;and S-LBL showed ideal sustained-release effects on GML rather than butyric acid, which may lead to positive changes in gut microbes.

Automated summary

S-BL and S-LBL obtained through structural adjustment showed ideal sustained-release effects on glycerol monolaurate in vitro and in vivo, and possibly had positive impacts on gut microbes.