Fucoxanthin-loaded nanoparticles composed of gliadin and chondroitin sulfate: Synthesis, characterization and stability

In this study, the fucoxanthin (FUC)-loaded gliadin nanoparticles (Gli NPs) stabilized by chondroitin sulfate (ChS) were fabricated. Results showed that the particle size and turbidity of Gli-ChS NPs were highly pHdependent. Hydrogen bond, electrostatic interaction and hydrophobic interaction were involved in the formation of Gli-ChS NPs. The surface hydrophobicity of Gli NPs decreased remarkably after coating with ChS. FUCGli-ChS NPs increased the stability of FUC against heating and ultraviolet (UV) irradiation. Adding ChS to FUCGli NPs enhanced their stabilities to ionic strength and thermal treatment, especially in an acidic environment. Furthermore, FUC-loaded Gli-ChS NPs inhibited the FUC release in simulated gastric fluid (SGF), while enhanced the release of FUC in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). In summary, this work has important practical significance for the development of Gli NPs as nano-delivery systems for FUC or other hydrophobic compounds.

Automated summary

This study reports the fabrication of fucoxanthin-loaded gliadin nanoparticles stabilized by chondroitin sulfate. The pH-dependency of particle size and turbidity of the nanoparticles was observed, and various interactions were involved in their formation. The addition of chondroitin sulfate improved the stability of the nanoparticles under different conditions. Moreover, the fucoxanthin-loaded nanoparticles exhibited controlled release behavior in simulated gastric, intestinal, and colonic fluids. Overall, this work has practical significance in the development of gliadin nanoparticles as nano-delivery systems for hydrophobic compounds.