Journal
FOOD CHEMISTRY
Volume 377, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.132006
Keywords
Fuzhuan brick tea; Obesity; Adipose tissue; Browning; Energy expenditure
Funding
- Main Research Program of Korea Food Research Institute - Ministry of Science and ICT [E0160500-05]
- Ministry of SMEs and Startups [GN 202500-01]
- National Research Council of Science & Technology (NST), Republic of Korea [E0160500-05] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Fuzhuan brick tea extract exerts anti-obesity effects by promoting browning of subcutaneous adipose tissue and enhancing energy expenditure.
Fuzhuan brick tea is a post-fermented tea that is intentionally fermented by the fungus Eurotium cristatum. Previous studies have reported the anti-obesity effect of Fuzhuan brick tea extracts (FBT), but the underlying mechanism remains unclear. The present study investigated whether FBT exerts anti-obesity effects through energy expenditure and browning of white adipose tissue. Mice were administered 100 mg or 200 mg FBT/kg body weight along with a high-fat diet (HFD) for 12 weeks; the FBT group had a significantly reduced body weight and adipose tissue mass compared to mice fed an HFD alone. FBT also improved serum biochemical parameters and hepatic steatosis concomitant with obesity. Furthermore, FBT enhanced energy expenditure and promoted browning of subcutaneous adipose tissue by upregulating the expression of brown adipocyte-specific genes, including uncoupling protein 1. Based on these results, we suggest that FBT induces energy expenditure by promoting the browning of subcutaneous adipose tissue, which prevents weight gain.
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