4.7 Article

Ti3C2Tx MXenes loaded with Au nanoparticle dimers as a surface-enhanced Raman scattering aptasensor for AFB1 detection

Journal

FOOD CHEMISTRY
Volume 372, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.131293

Keywords

MXenes; Au nanoparticle dimers; SERS; AFB1; Detection

Funding

  1. National Natural Science Foundation of China [3217161084]
  2. Guangzhou Key Laboratory for Intelligent Sensing and Quality Control of Agricultural Products [202102100009]
  3. Guangdong Provincial Science and Technology Plan Projects [2020A1414010160]
  4. Guangdong Basic and Applied Basic Research Foundation [2020A1515010936]
  5. Contemporary International Collaborative Research Centre of Guangdong Province on Food Innovative Processing and Intelligent Control [2019A050519001]
  6. Common Technical Innovation Team of Guangdong Province on Preservation and Logistics of Agricultural Products [2021KJ145]

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A ratiometric surface-enhanced Raman scattering (SERS) aptasensor for AFB1 detection was developed utilizing BPE to trigger the assembly of AuNP dimers and the interaction between MXenes nanosheets and aptamer-modified AuNP dimers. The sensor showed promising results in detecting AFB1 with a limit of detection (LOD) of 0.6 pg.mL(-1) in standard solution.
Mycotoxin B1 (AFB1) contamination in agricultural products pose a deadly danger to animal and human health and its rapid and reliable detection is thus very important. Herein, a ratiometric surface-enhanced Raman scattering (SERS) aptasensor for AFB1 detection was developed, in which 1,2-bis(4-pyridyl) ethylene (BPE) was used to trigger the assembly of Au nanoparticle dimers (AuNP dimers) and form intensive SERS hot spots, and MXenes nanosheets could load aptamer-modified AuNP dimers due to the hydrogen bonding and the chelation between the phosphate groups of aptamers and the Ti ion of MXenes. With the presence of AFB1 preferentially binding to AFB1 aptamer, AuNP dimers were separated from MXenes nanosheets, leading to a decrease in SERS intensity. Regression analysis in the range from 0.001 to 100 ng.mL(-1) showed the limit of detection (LOD) being 0.6 pg.mL(-1) in standard solution, indicating that the great prospects of the AuNP dimers/MXenes SERS substrate for detecting AFB1.

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