4.7 Article

An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans

Journal

FOOD AND CHEMICAL TOXICOLOGY
Volume 162, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2022.112914

Keywords

Alzheimer disease; DAF-16; FOXO; HSP-16; 2; IIS pathway; RNAi; SKN-1; NRF2

Funding

  1. FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento [B-AGR-193-UGR18]
  2. MCIN/AEI/FEDER Una manera de hacer Europa [PID2019-106778RB-I00]

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This study characterized an olive leaf extract enriched in oleuropein and found that it exhibited no toxicity and improved oxidative stress and proteotoxicity. The study also identified potential molecular mechanisms involving multiple signaling pathways.
Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against A beta induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to A beta and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved.

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