Journal
FITOTERAPIA
Volume 157, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2021.105120
Keywords
Limonoids; Walsura yunnanensis; Cytotoxic activity; Apoptosis; Cell cycle arrest
Categories
Funding
- National Natural Science Foundation of China [32000548, 82073740]
- Natural Science Foundation of Yunnan Province [202001AT070053, 202001AT070055]
- State Key Laboratory of Phytochemistry and Plant Resources in West China [P2018-ZZ05, P2019-ZZ06, P2021-ZZ04]
- Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China
Ask authors/readers for more resources
In this study, three new limonoids were isolated from Walsura yunnanensis, and their cytotoxic activity against human cancer cells was evaluated. The compounds showed significant inhibition of cell growth and induced cell cycle arrest and apoptosis.
Three new limonoids, walsurauias A-C (1-3), along with four known ones, were isolated from the leaves and twigs of Walsura yunnanensis C. Y. Wu. Their structures were determined on the basis of comprehensive spectroscopic data analysis. The new limonoids were screened for their cytotoxic activity (IC50 0.81-5.73 mu M) against four human cancer cell lines, including A549, HepG2, HCT116 p21KO and CNE-2. And alpha,beta-unsaturated ketone moieties in rings A and B are essential for their cytotoxic activity. Selected compounds were further investigated. Compounds 1-3 effectively induced G2/M cell cycle arrest and apoptosis in a dose-dependent manner in cancer cells. In addition, compounds 1-3 inhibited the colony formation and compounds 2 and 3 suppressed the migration of cancer cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
