Journal
FITOTERAPIA
Volume 159, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2022.105180
Keywords
Salvia miltiorrhiza; Isolation and purification; Phenolic acids; Structural elucidation; Neuroprotective activity
Categories
Funding
- Fundamental Research Funds for CAMS/PUMC [2018RC350011]
- Drug Innovation Major Project [2018ZX09711001-008-002]
- Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2017-I2M-3-010]
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Seven new phenolic acids were isolated from the roots of Salvia miltiorrhiza. Compound 4 exhibited a moderate neuroprotective activity.
Seven new phenolic acids, 7, 8-epiblechnic acid (1), 8-epiblechnic acid 9-ehthyl-9 & PRIME;-methyl ester (2), 9 & PRIME;-ehyl-isolithospermate (3), 9 & DPRIME;-methyl-isolithospermate (4), 9 & PRIME;-ethyl-9 & DPRIME;-methyl-isolithospermate (5), 9 & PRIME;, 9 & DPRIME;-dimethyl-isolithospermate (6), sebesteniod E (7), were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by detailed spectroscopic means including UV, IR, HRESIMS, and NMR data spectra. The bioactive assays of compounds 1-7 against neuroprotection activities were determined. The results suggested that compound 4 exhibited a moderate glutamate-induced neuroprotective activity and the cell survival rate was 24.0% (10-5 mol/L), while compound 2 showed weak activity (survival rate: 7.58%, 10-5 mol/L), using PHPB (survival rate: 7.56%, 10-5 mol/L) as positive control.
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