Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 122, Issue -, Pages 67-70Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2021.12.021
Keywords
Glyphosate-based herbicide; Intergenerational toxicity; Viral challenge; Cumulative mortality; Immunotoxicity
Funding
- Departement des Cotes d'Armor
- Agglomeration de Saint Brieuc
- Region Bretagne
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This study investigated the intergenerational toxicity of glyphosate and its formulations on rainbow trout and found that the nature of the formulations can modulate the susceptibility of fish to pathogens.
Glyphosate, the most widely used herbicide active substance worldwide, has raised many scientific, political and public debates in the context of its recent re-registration in the European Union, highlighting in particular a lack of data concerning its potential generational effects. In this study, we investigated the intergenerational toxicity of this active substance used alone or coformulated in glyphosate-based herbicides (GBHs) on the ability of rainbow trout (Oncorhynchus mykiss) to face a viral challenge. Juvenile trout from parents exposed for eight months to four different chemical exposure conditions (non-exposed control, pure glyphosate, Roundup Innovert (R), and Viaglif Jardin (R) were experimentally infected with the infectious hematopoietic necrosis virus (IHNv). Various enzymatic and hemato-immunological markers were assessed before and after the viral challenge. Chemical contamination with GBHs strongly modulated viral trout susceptibility. Pure glyphosate induced a cumulative mortality of 35.8%, comparable to the control (37.0%), which was significantly reduced with Roundup Innovert (R) (-9.9%) and increased (+14.8%) with Viaglif Jardin (R). No modification was observed for the biomarkers analysed for any conditions. These results demonstrate that the nature of the co-formulants associated to glyphosate in GHBs can modulate the susceptibility of fish to pathogens.
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