Multi-scale Nano/Micro Fiber Scaffolds with Different Topological Morphologies

The multi-scale fiber and topological morphologies had been shown to influence cell mitogenesis and chemotaxis, direct cell differentiation, and induce constructive host tissue remodeling responses. To simulate multi-layer meshwork architecture of extracellular matrix and regulate cell behavior, we prepared different topological scaffolds, such as 3D printing fiber scaffolds, poly(lactic acid) (PLA) electrospun fiber scaffolds, 3D printing/knitted fabric composite scaffolds, and PLA electrospinning/knitted fabric composite scaffolds. The surface morphology, pore diameter, thickness, stress-strain curve, electrical current, and other properties were studied. The aim is to prepare multi-scale nano/micro fiber scaffolds with different topological morphologies and properties that can provide structural and mechanical support for potential tissue engineering applications.

Automated summary

Multi-scale fiber and topological morphologies play a crucial role in influencing cell behavior and can be utilized in tissue engineering applications by preparing scaffolds with different topological morphologies and properties.