Live birth and pregnancy rates after in vitro fertilizati on/intracytoplasmic sperm injection in women with previous unilateral oophorectomy: a systematic review and meta-analysis

Objective: To quantify the effect of unilateral oophorectomy (UO) on the rates of live birth and pregnancy in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Design: Systematic review and meta-analysis. Setting: Search of databases of published articles. Patient(s): The final analytical cohort encompassed 1,057 IVF/ICSI cycles in women with previous UO and 45,813 IVF/ICSI cycles in control women. Eighteen studies were identified by database searches of MEDLINE, Embase, Web of Science, and cited references. The review encompassed studies published up to June 1, 2021. Intervention(s): UO prior to IVF/ICSI. Main Outcome Measure(s): The primary outcomes were the rates of live birth and pregnancy following IVF/ICSI. The secondary outcomes included the amount of gonadotropins administered for ovarian stimulation and the number of retrieved oocytes. Result(s): The studies were rated from medium to high quality (from 5 to 8) according to the Newcastle-Ottawa Quality Assessment Scale. All studies were observational, with inherent bias, and heterogeneity was high. The primary outcome of live birth had a significantly lower odds ratio (OR) in women with previous UO compared with controls (OR = 0.72, 95% confidence interval [CI] 0.57 to 0.91, z = -2.72). The OR for pregnancy rate per initiated treatment cycle was also significantly lower in women with previous UO compared with controls (OR = 0.70, 95% CI 0.57 to 0.86, z = -3.35). Additionally, the dose of administered gonadotropins was significantly higher and the number of retrieved oocytes was significantly lower in women with UO. Conclusion(s): The meta-analysis showed a significant detrimental effect of UO on the rates of live birth and pregnancy. The analysis further supports previous data showing a decreased sensitivity to gonadotropins and a lower number of recovered oocytes in women with previous UO. (C) 2022 by American Society for Reproductive Medicine.

Automated summary

This study conducted a systematic review and meta-analysis to quantify the impact of unilateral oophorectomy (UO) on the rates of live birth and pregnancy in women undergoing IVF/ICSI. The results showed that women with previous UO had significantly lower rates of live birth and pregnancy, as well as higher doses of administered gonadotropins and a lower number of retrieved oocytes.