4.5 Article

The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid-beta by microglia

Related references

Note: Only part of the references are listed.
Review Cell Biology

The exosome journey: from biogenesis to uptake and intracellular signalling

Sonam Gurung et al.

Summary: Exosomes have vast potential in clinical applications, and understanding their biology is crucial. The processes of exosome biogenesis, transport, and uptake involve numerous influencing factors.

CELL COMMUNICATION AND SIGNALING (2021)

Article Chemistry, Multidisciplinary

Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison

Jun-Yong Wu et al.

Summary: The study compared Exos and BNVs for brain tumor drug delivery, finding that BNVs derived from brain-derived endothelial cells are a promising alternative with higher yield and similar drug-loading capacity to natural exosomes. Despite different mechanisms, BNV/DOX showed similar therapeutic effects to Exo/DOX in inhibiting the progression of glioblastoma, with minimal systemic toxicity. The findings suggest that autologous BNVs are an effective alternative to Exos for brain tumor nanomedicine.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Medicine, Research & Experimental

Clinical applications of exosome membrane proteins

Qian Hu et al.

PRECISION CLINICAL MEDICINE (2020)

Article Multidisciplinary Sciences

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

Lin Song et al.

NATURE COMMUNICATIONS (2019)

Review Geriatrics & Gerontology

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities

Anne-Laure Hemonnot et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Biotechnology & Applied Microbiology

Isolation of microglia-derived extracellular vesicles: towards miRNA signatures and neuroprotection

Quentin Lemaire et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Aß42 Protofibrils Interact with and Are Trafficked through MicroglialDerived Microvesicles

Lisa K. Gouwens et al.

ACS CHEMICAL NEUROSCIENCE (2018)

Article Cell Biology

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Scott W. Messenger et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Geriatrics & Gerontology

TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism

Honghua Zheng et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Chemistry, Multidisciplinary

Exosomes: new molecular targets of diseases

Saheli Samanta et al.

ACTA PHARMACOLOGICA SINICA (2018)

Review Biochemistry & Molecular Biology

TREM2, Microglia, and Neurodegenerative Diseases

Felix L. Yeh et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Tyler K. Ulland et al.

Article Multidisciplinary Sciences

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

Karpagam Srinivasan et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model

Yaming Wang et al.

Article Medicine, Research & Experimental

TREM2 sustains microglial expansion during aging and response to demyelination

Pietro Luigi Poliani et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Neurosciences

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Hirohide Asai et al.

NATURE NEUROSCIENCE (2015)

Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Biochemistry & Molecular Biology

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

P. Joshi et al.

CELL DEATH AND DIFFERENTIATION (2014)

Review Immunology

Exosomes as mediators of neuroinflammation

Archana Gupta et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Cell Biology

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Gernot Kleinberger et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Neurosciences

The microglial sensome revealed by direct RNA sequencing

Suzanne E. Hickman et al.

NATURE NEUROSCIENCE (2013)

Editorial Material Medicine, General & Internal

Variant TREM2 as Risk Factor for Alzheimer's Disease

Harald Neumann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Thorlakur Jonsson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

Kate Koles et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Michelle C. Mendoza et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Editorial Material Cell Biology

Two Rabs for exosome release

Suzanne R. Pfeffer

NATURE CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

Christine L. Hsieh et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Review Cell Biology

Rab GTPases as coordinators of vesicle traffic

Harald Stenmark

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)