Journal
FAMILIAL CANCER
Volume 22, Issue 1, Pages 19-30Publisher
SPRINGER
DOI: 10.1007/s10689-022-00296-y
Keywords
Belarus; BRCA1; 2; Breast cancer; Founder mutations; Ovarian cancer
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The study found that BRCA1/2 gene mutations in Belarusian population show a high level of founder allele effect. This is surprising as the population of Belarus did not experience geographic or cultural isolation throughout history.
The spectrum of BRCA1/2 mutations demonstrates significant interethnic variations. We analyzed for the first time the entire BRCA1/2 coding region in 340 Belarusian cancer patients with clinical signs of BRCA1/2-related disease, including 168 women with bilateral and/or early-onset breast cancer (BC), 104 patients with ovarian cancer and 68 subjects with multiple primary malignancies involving BC and/or OC. BRCA1/2 pathogenic alleles were detected in 98 (29%) women, with 67 (68%) of these being represented by founder alleles. Systematic comparison with other relevant studies revealed that the founder effect observed in Belarus is among the highest estimates observed worldwide. These findings are surprising, given that the population of Belarus did not experience geographic or cultural isolation throughout history.
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