Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 19, Issue 4, Pages 421-433Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17425247.2022.2061459
Keywords
Digestive cancer; drug delivery; anti-cancer drugs; ultrasound; microbubble
Categories
Funding
- INCa/DGOS PRTK15-TK/Sonchimio [2017000159-15]
- Ligue Contre le Cancer
- Canceropole Grand-Ouest
- Inserm
- University of Tours
Ask authors/readers for more resources
The combination of microbubbles and ultrasound is a promising method for enhancing intratumor chemotherapeutic uptake while reducing systemic adverse effects. Current studies have mainly focused on subcutaneous models of digestive cancers, but further evaluation is needed in relevant preclinical animal models and clinical trials to provide solid evidence.
Introduction The combination of microbubbles (MBs) and ultrasound (US) is an emerging method for the noninvasive and targeted enhancement of intratumor chemotherapeutic uptake. This method showed an increased local drug extravasation in tumor tissue while reducing the systemic adverse effects in various tumor models. Area covered We focused on preclinical and clinical studies investigating the therapeutic efficacy and safety of this technology for the treatment of colorectal, pancreatic, and liver cancers. We discussed the limitations of the current investigations and future perspectives. Expert opinion The therapeutic efficacy and the safety of delivery of standard chemotherapy regimen using MB-assisted US have been mainly demonstrated in subcutaneous models of digestive cancers. Although some clinical trials on pancreatic ductal carcinoma and hepatic metastases from various digestive cancers have shown promising results, successful evaluation of this method in terms of US settings, chemotherapeutic schemes, and MBs-related parameters will need to be addressed in more relevant preclinical models of digestive cancers, in small and large animals before fully and successfully translating this technology for clinic use. Ultimately, a clear evidence of the correlation between the enhanced intratumoral concentrations of therapeutics and the increased therapeutic response of tumors have to be provided in clinical trials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available