SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD(+))-dependent enzyme. It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses. Recently, SIRT6 has emerged as a prominent research issue because its biochemical activity and regulation are possibly associated with human metabolism and disease. In this review, we summarized the connection between SIRT6 and glycolytic metabolism; discussed recent developments in the involvement of SIRT6 in a variety of life-threatening illnesses, including cancer, neurodegenerative diseases and cardiovascular disease; and explored possible treatment approaches for those diseases with SIRT6. This review provides insights into the role of SIRT6 in disease.

Automated summary

This review summarizes the connection between SIRT6 and glycolytic metabolism, discusses its involvement in life-threatening diseases like cancer, neurodegenerative diseases, and cardiovascular disease, and explores possible treatment approaches using SIRT6.