Journal
EXPERIMENTAL EYE RESEARCH
Volume 219, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2022.109033
Keywords
Photoreceptor; Cone; Rod; Material transfer; STORM; Cell -cell connection
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [AD375/6-1, FZT 111, EXC68]
- Funding Programs for DZNE Helmholtz
- TU Dresden CRTD
- DFG [KA2794/5-1 SPP2127]
- Molecular Imaging and Manipulation Facility
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Transplantation of photoreceptor cells in mouse retina can lead to cytoplasmic material transfer mediated by nanotube-like structures. Evidence suggests that this transfer process also occurs between endogenous cones and endogenous rods in the mouse retina, with preliminary data indicating similar material transfer in the human retina.
Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor ma-terial transfer process is likely to be mediated by nanotube-like structures connecting donor and host photore-ceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.
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