Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1a pathway

Review Biochemistry & Molecular Biology

Transcription Factor Movement and Exercise-Induced Mitochondrial Biogenesis in Human Skeletal Muscle: Current Knowledge and Future Perspectives

Dale F. Taylor et al.

Summary: This review summarizes and critically analyzes the published literature on the exercise-induced movement of transcription factors involved in mitochondrial biogenesis in skeletal muscle.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling

Mei Yu et al.

Summary: This study demonstrates that baicalin alleviates insulin resistance and metabolic dysfunction through activation of the GALR2-GLUT4 signaling pathway. These findings offer a new therapeutic approach for the treatment of insulin resistance and type 2 diabetes mellitus.

PHYTOMEDICINE (2022)

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Article Cell Biology

Functional and Genetic Characterization of Porcine Beige Adipocytes

Lilan Zhang et al.

Summary: This study compares the gene expression profiles between white and beige adipocytes from Tibetan piglets and identifies two genes involved in beige adipocyte differentiation and thermogenesis. Understanding the genetic basis of beige adipogenesis in pigs will have implications for molecular breeding in pigs and large animal models of human diseases.

CELLS (2022)

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Review Biochemistry & Molecular Biology

The colorful versatility of adipocytes: white-to-brown transdifferentiation and its therapeutic potential in man

Stefanie Maurer et al.

Summary: Understanding the conversion of brown and brite adipocytes is crucial for improving metabolic disorders, and identifying novel browning agents is necessary before this adipocyte transdifferentiation can be realized as a safe and efficacious therapy in humans.

FEBS JOURNAL (2021)

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Review Endocrinology & Metabolism

The evolving view of thermogenic adipocytes - ontogeny, niche and function

Farnaz Shamsi et al.

Summary: Obesity and metabolic disorders are highly related to adipose tissue, and activating and expanding BAT and beige adipose tissue can increase energy expenditure and potentially treat obesity.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Cell Biology

The cellular and functional complexity of thermogenic fat

Paul Cohen et al.

Summary: Brown and beige adipocytes are mitochondria-enriched cells that can dissipate energy in the form of heat, regulating whole-body energy metabolism. They have diverse functions beyond thermogenesis, acting as metabolite sinks, secretory cells, and regulators of adipose tissue homeostasis, ultimately contributing to improved metabolic health.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis

Christel L. Roth et al.

Summary: The specific abilities of brown and beige adipocytes to induce non-shivering thermogenesis have shown therapeutic potential in metabolic disorders like obesity and diabetes, as well as in the development of atherosclerosis. Cold exposure can promote the activation of these thermogenic adipose tissues, leading to decreased plasma lipid levels and atheroprotective effects.

METABOLITES (2021)

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Review Pharmacology & Pharmacy