Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 921, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2021.174669
Keywords
Narciclasine; Esophageal cancer cell; Migration; FAK; MAPK
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Funding
- National Research Foundation (NRF) of Korea - Korean government (MSIT) [NRF-2018R1C1B5083127]
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Narciclasine inhibits proliferation and migration of esophageal cancer cells through FAK/JNK and p38 pathways, accompanied by DNA damage, cell cycle arrest, and apoptosis.
Esophageal cancer (EC) is one of the malignant cancer with pool survival due to the limited therapeutic and drug resistance. Narciclasine, a natural compound from Lycoris sanguinea possesses antitumor and anti-inflammatory properties. However, the mechanisms underlying the growth-inhibitory effect of narciclasine against EC have not yet been elucidated. Experimental evidences indicated that narciclasine treatment significantly affected the distribution of FAK and its phosphorylation, resulting in proliferation inhibition and migration inhibition of EC. Our study also showed that narciclasine treatment triggered DNA damage and inhibited DNA replication, leading to cell cycle arrest and apoptosis. Further mechanistic studies indicated that narciclasine inhibited EC cell proliferation and migration through FAK/JNK and p38 pathway. Altogether, these findings suggest that narciclasine could be a potential novel chemotherapeutic agent for esophageal cancer cell proliferation and migration.
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