Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2022, Issue 33, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202101517
Keywords
C-H activation; Glycinamides; Multicomponent reactions; Picolinamide; Ugi-ammonia reaction
Categories
Funding
- DGAPA-UNAM [PAPIIT IN205721]
- CONACyT [585699]
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A Pd(II)-catalyzed C(sp(2)/sp(3))-H bond arylation protocol has been developed for the synthesis of ortho-diaryl, ortho-mono-aryl, and biaryl-diarylmethane-glycinamide derivatives bearing picolinamide as a directing group. Mechanistic details were investigated through computational modeling using DFT calculations.
A Pd(II)-catalyzed C(sp(2)/sp(3))-H bond arylation protocol has been developed to access ortho-diaryl, ortho-mono-aryl, and biaryl-diarylmethane-glycinamide derivatives bearing picolinamide as directing group. Mechanistic details of the process have been obtained by computational modelling of the activation reaction through DFT calculations.
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