Journal
JOURNAL DE MYCOLOGIE MEDICALE
Volume 26, Issue 2, Pages 160-169Publisher
MASSON EDITEUR
DOI: 10.1016/j.mycmed.2016.03.001
Keywords
Streptomyces; Taxonomy; Antifungal activity; Candida albicans; 2,4-Di-tert-butylphenol
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Funding
- Comite mixte Franco-Algerien de l'Accord Programme TASSILI (PHC) [15 MDU 932]
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In a search for new antifungal antibiotics active against Candida albicans and others pathogenic fungi, a strain of actinobacteria, designated G61, was isolated from a Saharan soil and tested for its activity against these microorganisms. The analysis of its 16S rDNA sequence showed a similarity level of 100% with Streptomyces mutabilis NBRC 12800(T). The highest anticandidal activities produced by the strain G61 were obtained on Bennett medium in the fourth day of incubation. The active product, extracted by n-butanol, contained one bioactive spot detected on thin layer chromatography plates. It was purified by HPLC and its chemical structure was determined by spectroscopic analyses as 2,4-Di-tert-butylphenol. The minimum inhibitory concentrations (MIC) of this product against several strains of pathogenic microorganisms are interesting. (C) 2016 Elsevier Masson SAS. All rights reserved.
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