Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases

SUMOylation is a key post-translational modification that involves the covalent attachment of small ubiquitin-like modifier (SUMO) to the lysine residues of target proteins. The well-balanced SUMOylation is essential for normal cellular behaviors, while disturbance of SUMOylation is associated with various cancers and other diseases. Herein, we summarize the structures and biological functions of proteins involved in the SUMOylation process, their dysregulation in human diseases, and the discovery of small-molecular inhibitors targeting this pathway. In addition, we highlight the emerging trends in this field.(c) 2022 Elsevier Masson SAS. All rights reserved.

Automated summary

SUMOylation is a key post-translational modification process that is essential for normal cellular functions. Dysregulation of SUMOylation is associated with various diseases, and small-molecular inhibitors targeting this pathway have been discovered.