Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume 2022, Issue 15, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.202200097
Keywords
Antitumor agents; Cobalt; Nanoparticles; Structure elucidation; Tetrazole carboxylate ligands
Categories
Funding
- National Natural Science Foundation of China [21171093, 21476115, 11405014]
- Jiangsu Science and Technology Department of China [BY2015043-02]
- Natural Science Fund of Jiangsu Province of P. R. China [14KJB150001, BK20131212]
Ask authors/readers for more resources
In this study, three coordination complexes were synthesized and nanoparticlized through self-assembly. These complexes exhibited excellent cytotoxicity, especially against HeLa cells. The effect of different ligands on anticancer activity was also explored, providing a new strategy for designing efficient anticancer materials based on coordination complexes.
As a kind of multifunctional materials with high porosity, tunable pore structure and easy functionalization, coordination complexes have been widely used in various fields. Here, three complexes were prepared by self-assembly with Co(II) ions using tetrazolylacetic acids as ligands, 2,2 ',2 ''-(benzene-1,3,5-triyltris(2H-tetrazole-5,2-diyl)) triacetic acid (H(3)tzpha), 2-(5-(pyrazin-2-yl)-2H-tetrazol-2-yl) propanoic acid (Hpztzma) and 2-(5-(pyridin-2-yl)-2H-tetrazol-2-yl) acetic acid (Hpytza), and were characterized by X-ray crystallography. These complexes can also self-assemble into nanoparticles (NPs) in aqueous solution by nanocoprecipitation. In vitro CCK-8 assay on three kind of human cancer cells (HeLa, HepG2 and Huh7) cells showed these Co(II) complexes have the best cytotoxicity against HeLa cells. And complex 1 had a half maximal inhibitory concentration (IC50 value) of 14.8 mu g mL(-1), which was superior to 16.5 mu g mL(-1) and 15.2 mu g mL(-1) of complex 2 and 3. In addition, the effect of different ligands on cancer cell ablation was explored. The results showed the three NPs can effectively inhibit the proliferation of cancer cells in vitro and provided a strategy on designing highly efficient anticancer materials based on coordination complexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available