4.5 Review

IL-13 in dermal type-2 dendritic cell specialization: From function to therapeutic targeting

Journal

EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 52, Issue 7, Pages 1047-1057

Publisher

WILEY
DOI: 10.1002/eji.202149677

Keywords

Atopic dermatitis; Dendritic cells; IL-13; Innate lymphoid cells; Th2 immune responses

Categories

Funding

  1. Health Research Council of New Zealand Independent Research Organization

Ask authors/readers for more resources

Skin functions as a protective barrier and is inhabited by various immune cells. This review focuses on the specialization of antigen-presenting cells in the skin and the role of IL-13 cytokine in immune responses. The impact of IL-13-blocking therapeutics on antigen-presenting cells in human skin is also discussed.
Skin functions as a barrier protecting the host against physical, thermal, chemical changes as well as microbial insults. The skin is populated by several immune cell types that are crucial to host defense and to maintain self-tolerance as well as equilibrium with beneficial microbiota. Conventional dendritic cells (cDCs) are antigen-presenting cells that patrol the skin and all other nonlymphoid tissues for self or foreign antigens, and then migrate to draining lymph nodes to initiate T-cell responses. This review article describes recent developments on skin cDC specialization, focusing on the role of IL-13, a cytokine essential to allergic immune responses that is also secreted at steady state by type-2 innate lymphoid cells in healthy skin, and is required for dermal cDC differentiation. Furthermore, we contextualize how different therapeutics that block IL-13 signaling and were recently approved for the treatment of atopic dermatitis might affect cDCs in human skin.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available